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Chemical Structure : YM-201636
CAS No.: 371942-69-7
Catalog No.: PC-43409Not For Human Use, Lab Use Only.
YM-201636 is a potent, selective PIKfyve inhibitor with IC50 of 33 nM, does not inhibit type Iiγ/Iα PtdInsP kinases even at 10 uM (p110α IC50=3.3 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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YM-201636 is a potent, selective PIKfyve inhibitor with IC50 of 33 nM, does not inhibit type Iiγ/Iα PtdInsP kinases even at 10 uM (p110α IC50=3.3 uM).
YM-201636 shows insensitivity against yeast orthologue of PIKfyve, Fab1; significantly decreases the production of PtdIns(3,5)P2 by 80% in serum-starved NIH3T3 cells with no effect on serum-stimulated PKB Ser 473 phosphorylation at 0.8 uM.
YM-201636 inhibits basal and insulin-activated 2-deoxyglucose uptake withIC50 of 54 nM.
YM-201636 significantly reduces retroviruses budding from cells; blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells.
| M.Wt | 467.4793 | |
| Formula | C25H21N7O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 47 mg/mL |
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| Chemical Name/SMILES |
3-Pyridinecarboxamide, 6-amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]- |
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1. Jefferies HB, et al. EMBO Rep. 2008 Feb;9(2):164-70.
2. Osborne SL, et al. J Biol Chem. 2008 Feb 1;283(5):2804-13.
3. Ikonomov OC, et al. Biochem Biophys Res Commun. 2009 May 8;382(3):566-70.
4. Kerr MC, et al. EMBO J. 2010 Apr 21;29(8):1331-47.
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