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Chemical Structure : YM-90709
CAS No.: 163769-88-8
Catalog No.: PC-45769Not For Human Use, Lab Use Only.
A potent IL-5 receptor antagonist that inhibits the binding of IL-5 to its receptor on peripheral human eosinophils and butyric acid-treated eosinophilic HL-60 clone 15 cells with IC50 of 1.0 and 0.57 uM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $120 | In stock | |
| 25 mg | $200 | In stock | |
| 50 mg | $360 | In stock |
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A potent IL-5 receptor antagonist that inhibits the binding of IL-5 to its receptor on peripheral human eosinophils and butyric acid-treated eosinophilic HL-60 clone 15 cells with IC50 of 1.0 and 0.57 uM, respectively; inhibits IL-5-prolonged eosinophil survival with IC50 of 0.45 uM and does not affect the GM-CSF-prolonged eosinophil survival; inhibits antigen-induced infiltration of eosinophils and lymphocytes into the bronchoalveolar lavage fluid (BALF) in BN rats (EC50=0.32 mg/kg and 0.12 mg/kg, respectively).
| M.Wt | 359.4211 | |
| Formula | C22H21N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benz[7,8]indolizino[2,3-b]quinoxaline, 5,6-dihydro-2,3-dimethoxy-6,6-dimethyl- |
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1. Morokata T, et al. Int Immunopharmacol. 2002 Nov;2(12):1693-702.
2. Morokata T, et al. Int Immunopharmacol. 2004 Jul;4(7):873-83.
3. Morokata T, et al. Immunol Lett. 2005 Apr 15;98(1):161-5.
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