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Chemical Structure : Zaprinast
CAS No.: 37762-06-4
Catalog No.: PC-70272Not For Human Use, Lab Use Only.
Zaprinast (M&B 22948) is a potent, cGMP-specific phosphodiesterase inhibitor with IC50 of 0.5-0.76 and 0.15 uM for PDE5 and PDE6 respectively, also is an agonist for GPR35 (EC50=16/840 nM for rat/human GPR35).
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|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
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Zaprinast (M&B 22948) is a potent, cGMP-specific phosphodiesterase inhibitor with IC50 of 0.5-0.76 and 0.15 uM for PDE5 and PDE6 respectively, also is an agonist for GPR35 (EC50=16/840 nM for rat/human GPR35).
Zaprinast weakly inhibits PDE9, PDE10, and PDE11 with IC50 of 10-30 uM.
Zaprinast enhances the vasodilatory effects of nitric oxide in a range of vascular tissues by prolonging the cGMP-mediated activation of cGMP-dependent protein kinase.
Zaprinast also reduces cellular 2HG levels by inhibiting the upstream enzyme glutaminase (GLS), reverses histone hypermethylation and soft-agar growth of IDH1-mutant cells.
| M.Wt | 271.3 | |
| Formula | C13H13N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3,6-dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo[4,5-d]pyrimidin-7-one |
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2. Taniguchi Y, et al. FEBS Lett. 2006 Sep 18;580(21):5003-8.
3. Frossard N, et al. Br J Pharmacol. 1981 Aug;73(4):933-8.
4. Griffith TM, et al. Eur J Pharmacol. 1985 Jun 7;112(2):195-202.
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