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Chemical Structure : mPGES1-IN-17d
Catalog No.: PC-62797Not For Human Use, Lab Use Only.
mPGES1-IN-17d is a potent, selective mPGES-1 inhibitor with enzyme IC50 of 8 nM, A549 cell IC50 of 16.24 nM, human whole blood IC50 of 249.9 nM.
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mPGES1-IN-17d is a potent, selective mPGES-1 inhibitor with enzyme IC50 of 8 nM, A549 cell IC50 of 16.24 nM, human whole blood IC50 of 249.9 nM.
mPGES1-IN-17d displays excellent in vitro selectivity over mPGES-2, cPGES, COX1/2, other prostanoid synthases, favorable hERG and CEREP panel profile.
mPGES1-IN-17d shows good efficacy in LPS-induced thermal hyperalgesia pain model.
mPGES1-IN-17d demonstrates good oral pharmacokinetic profiles and good CNS B/P ratio in rat and guinea pig.
| M.Wt | 538.859 | |
| Formula | C24H16ClF5N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Muthukaman N, et al. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5977-5984.
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