| Cat. No. |
Product Name |
Information |
| PC-61441 |
Beloranib
MetAP2 inhibitor
|
Beloranib (ZGN-440) is an analog of the natural compound Fumagillin that functions as a highly potent methionine aminopeptidase 2 (MetAP2) inhibitor. |
| PC-60511 |
Firibastat
Aminopeptidase A inhibitor
|
Firibastat (QGC 001, RB 150) is a potent, orally active, centrally acting aminopeptidase inhibitor, the prodrug of the specific and selective aminopeptidase A inhibitor EC33. |
| PC-60469 |
CHR 2863
Aminopeptidase inhibitor
|
CHR 2863 is a potent, orally available hydrophobic aminopeptidase inhibitor that structurally mimics the aminopeptidase inhibitor Tostedostat. |
| PC-70071 |
Tosedostat
Aminopeptidase inhibitor
|
Tosedostat (CHR-2797, CHR2797) is a potent, orally bioavailable aminopeptidases inhibitor with IC50 of 150, 220 and 100 nM for PuSA, aminopeptidase N and leucine aminopeptidase, respectively. |
| PC-42712 |
DG051
LTA4H inhibitor
|
DG051 (DG-051) is a potent, selective LTA4H (Leukotriene A4 hydrolase) inhibitor (IC50/Kd=47/25 nM) of leukotriene B4 biosynthesis. |
| PC-22166 |
QHL1
IRAP inhibitor
|
QHL1 is a potent, selective insulin-regulated aminopeptidase (IRAP) inhibitor with IC50 of 320 nM. |
| PC-21697 |
HFI-419
IRAP inhibitor
|
HFI-419 is a specifc inhibits of insulin-regulated aminopeptidase (IRAP) with Ki of 0.48 uM, potent inhibits the hydrolysis of the dipeptidic substrate L-Leucine-7-amido-4-methylcoumarin with IC50 of 0.4 uM, >1000-fold lower or no affinity for related and unrelated enzymes. |
| PC-21190 |
Ubenimex
CD13 inhibitor
|
Ubenimex (Bestatin) is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase inhibitor with anticancer effects. |
| PC-20620 |
Actinonin
Aminopeptidase M inhibitor.
|
Actinonin is an isolated antibiotic and shown to be an inhibitor of aminopeptidase M, inhibits enkephalin-degrading enzymes from guinea-pig striatum (enkephalin-aminopeptidase), striatal membrane neutral endopeptidase and soluble dipeptidylaminopeptidase in rat whole brain homogenate with IC50 of 0.39, 5.6 and 1.1 uM, respectively. |
| PC-72273 |
IRAP-IN-1
IRAP inhibitor
|
IRAP-IN-1 is a selective insulin-regulated aminopeptidase (IRAP) inhibitor with IC50 of 32 nM, >25-fold selectivity over ERAP1 and ERAP2. |
| PC-72272 |
ERAP1 inhibitor 3
ERAP1 inhibitor
|
ERAP1 inhibitor 3 is a selective, small molecule inhibitor of ERAP1 with IC50 of 0.4 uM, displays no inhibitory effect against its paralogues ERAP2 and IRAP. |
| PC-72271 |
DG013A
ERAP1 inhibitor
|
DG013A (DG 013A) is tripeptide mimetic chemical probe (inhibitor) of ERAP1 with IC50 of 0.19 uM, 15-fold selectivity over ERAP2, potently inhibits aminopeptidase N (APN) with IC50 of 3.7 nM. |
