Cat. No. |
Product Name |
Information |
PC-47089 |
Tpz-1
PCD inducer
|
Tpz-1 is a unique cytotoxic compound that elicits potent and selective programmed cell death in human blood, breast, colon, and cervical cancer cell lines, interferes with components of signaling pathways and the cytoskeleton that are important to cell shape, internal organization, growth, and division. |
PC-73048 |
Leusin-1
ALL G2 phase inhibitor inhibitor
|
Leusin-1 (Leukemia specific inhibitor 1) is a cell cycle phase specific inhibitor that specifically arrest leukemia cells during G2-phase and triggers an apoptotic cell death (CCRF-CEM IC50= 2.66 uM and TOM1 IC50= 0.877 uM). |
PC-72413 |
WEHI-7326
Mitotic inhibitor
|
WEHI-7326 (WEHI 7326) is a specific mitotic inhibitor and potential anticancer agent, causes cell cycle arrest in G2/M, cell death in vitro (MDA-MB-231 IC50=24.4 nM), and displays efficacious anti-tumor activity in vivo. |
PC-36025 |
CCI-007
Apoptosis inducer
|
CCI-007 (CCI 007) is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia with IC50 of 3.5 uM against MLL-r leukemia cell line PER-485. |
PC-62586 |
NecroX-7
|
NecroX-7 is a small molecule necrosis modulator and potent antioxidant molecule, which can be bound to some types of radicals and especially NAPQI. |
PC-42276 |
JPH203
|
JPH203 (KYT-0353) is a potent, selective L-type amino acid transporter 1 (LAT1, SLC7A5) inhibitor with IC50 of 60 nM (leucine uptake inhibition), but not LAT2. |
PC-21768 |
Raptinal
Apoptosis inducer
|
Raptinal is a small molecule rapid apoptosis inducer, initiates intrinsic pathway caspase-dependent apoptosis in multiple cell lines, also inhibits the activity of caspase-activated Pannexin 1 (PANX1). |
PC-21095 |
EGCG
Anticancer
|
EGCG (Epigallocatechin-3-gallate) is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis, inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. |
PC-20272 |
ANP0903
|
ANP0903 is an analog of HIV-1 protease inhibitor darunavir, induces cytotoxicity in hepatocellular carcinoma cell lines, triggers apoptosis by enhancing ER stress. |
PC-38741 |
WZY-321
XAF1 modulator
|
WZY-321 a small molecule glioma cell apoptosis inducer, binds to XAF1 3-UTR and decreases XAF1 (X-linked inhibitor of apoptosis-associated factor 1) mRNA levels. |
PC-38723 |
Devimistat
KGDH inhibitor
|
CPI-613 (Devimistat) is an antimitochondrial metabolism agent that specifically induces inactivating phosphorylation of tumor cell PDH via stimulation of PDKs 1 to 4, inhibits KGDH function strongly and rapidly, selectively in tumor cells. |
PC-35324 |
Flavokawain B
|
Flavokawain B is a natural chalcone that can induce apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC50=3-50 uM), via up-regulation of death-receptor 5 and Bim expression. |