Cat. No. |
Product Name |
Information |
PC-73347 |
F114
Aurora/LIMK inhibitor
|
F114 is a novel, first-in-class, dual aurora and lim kinase inhibitor with IC50 of 72 nM and 137 nM against Aurora-A and Limk1, respectively, F114 inhibits GBM proliferation and invasion. |
PC-35756 |
LY3295668
|
LY3295668 (LY-3295668, AK-01) is a novel potent, highly selective, orally active Aurora-A kinase inhibitor with Ki of 0.8 nM, H446 AurA auto-P IC50 of 0.6 nM. |
PC-43432 |
AMG-900
Aurora kinases inhibitor
|
AMG-900 (AMG900) is a potent, highly selective, orally bioavailable pan-Aurora kinase inhibitor with IC50 of 5, 4 and 1 nM for Aurora A, B and C, respectively. |
PC-63253 |
BI 831266
AURKB inhibitor
|
BI 831266 is a potent, selective inhibitor of Aurora kinase B (AURKB) with IC50 of binding IC50 of 42 nM. |
PC-62560 |
AS 703569
Aurora kinases inhibitor
|
Cenisertib (AS 703569;R763) is a novel potent, orally available inhibitor of Aurora kinases, exhibits signifficant anti-proliferative activity against a wide range of tumor cells both in vitro and in vivo (A549 EC50=9 nM). |
PC-42342 |
Barasertib
AURKB inhibitor
|
Barasertib (AZD1152) is a potent, highly selective Aurora B inhibitor with IC50 of 0.37 nM. |
PC-42422 |
Danusertib
Aurora kinases inhibitor
|
Danusertib (PHA-739358) is a potent, ATP-competitive Aurora kinase inhibitor with IC50 of 13,79 and 61 nM for Aurora A, B and C, respectively. |
PC-45829 |
AT-9283
Aurora kinases inhibitor
|
AT-9283 is a multi-targeted kinase inhibitor with potent activity against Aurora A, Aurora B, JAK2, JAK3, and ABL (T315I) with IC50 of 3, 3, 1.2, 1.1, and 4 nM, respectively. |
PC-42409 |
Tozasertib
Aurora kinases inhibitor
|
Tozasertib (MK-0457, VX-680) is a highly potent, selective and reversible Aurora kinase inhibitor with Ki of 0.6, 18 and 4.6 nM for Aurora A, B and C, respectively. |
PC-21560 |
Reversine
Aurora Kinase inhibitor
|
Reversine is a potent, ATP-competitive Aurora kinases inhibitor with IC50 of 400, 500 and 400 nM for Aurora A, Aurora B and Aurora C, respectively. |
PC-21147 |
Ilorasertib
Aurora Kinase inhibitor
|
Ilorasertib (ABT-348) is a potent inhibitor of Aurora kinases as well as the VEGF and PDGF families of receptor tyrosine kinases (Aur B IC50=2 nM, PDGFRβ IC50=3 nM). |
PC-20713 |
LXY18
AURKB inhibitor
|
LXY18 is a potent orally available blocker of AURKB relocation in mitosis with minimum effective concentration (MEC) of 3.5 nM for inducing polyploidy, shows broad-spectrum growth inhibitory and apoptosis-inducing activities with low nanomolar potencies. |