| Cat. No. |
Product Name |
Information |
| PC-49758 |
COE2-2hexyl
|
COE2-2hexyl is a broad-spectrum antibacterial conjugated oligoelectrolyte (COE), does not evoke bacterial resistance, inhibits methicillin-resistant S. aureus (MRSA, MT3302) with MIC of 1 ug/mL. |
| PC-49691 |
Nifuroxazide
|
Nifuroxazide (NFX) is a broad-spectrum antibacterial agent, also exhibits potent inhibition of the transcription factor STAT3, also inhibits ERG-mediated transcription. |
| PC-49547 |
JMV-7061
MBL inhibitor
|
JMV7061 (JMV-7061) is a novel potent, selective bacterial metallo-β-lactamase (MBL) inhibitor, shows submicromolar activities against VIM-type enzymes and strong NDM-1 inhibition (Ki=10-30 nM). |
| PC-49388 |
MRV03-069
ClbP inhibitor
|
MRV03-069 is a small molecule compound that potently and specifically inhibit the colibactin-activating peptidase ClbP (IC50=28 nM), inhibits colibactin-associated genotoxicity. |
| PC-49326 |
TPP8
DNA Gyrase inhibitor
|
TPP8 is a small molecule antibacterial inhibiting the ATPase of DNA gyrase with IC50 of 0.3 uM, binds and inhibits the ATPase domain of the gyrase B subunit, shows activity against M. abscessus strains with MIC of 0.04-0.2 uM. |
| PC-49315 |
Fabimycin
FabI inhibitor
|
Fabimycin is a potent, specific inhibitor of the enoyl-acyl carrier protein reductase enzyme FabI, exhibits impressive activity against >200 clinical isolates of Escherichia coli, Klebsiella pneumoniae (MIC, 1 ug/mL), and Acinetobacter baumannii, and does not kill commensal bacteria. |
| PC-49257 |
JSF-2659
|
JSF-2659 is the orally bioavailable, phosphate prodrug of JSF-2414, JSF-2659 (100 and 250 mg/kg, p.o.) is highly efficacious in reducing microbial burdens in animal models of Neisseria gonorrhoeae vaginal infection as well as VRSA and C. difficile-induced colitis models. |
| PC-49162 |
Sudapyridine
Anti-M.tb
|
Sudapyridine (WX-081) is a potential new antituberculosis compound,excellent antimicrobial in vitro activity against both drug-susceptible and drug-resistant M. tuberculosis clinical isolates with MICs of 0.117 to 0.219 ug/mL. |
| PC-49157 |
JBD1
|
JBD1 is a small molecule compound that strongly inhibits biofilm formation of S. aureus, including methicillin-resistant strains, induces biofilm inhibition and metabolic remodeling through respiratory activation. |
| PC-47052 |
VU0026921
|
VU0026921 is a small molecule modulator of metal homeostasis in gram-positive pathogens, disrupts metal homeostasis in multiple Gram-positive bacteria, leading to increased reactive oxygen species and cell death. |
| PC-47041 |
D66
|
D66 is a specific small molecule that disrupts S. Typhimurium membrane voltage without cell lysis, prevents S. Typhimurium survival in macrophages (IC50=6.0 uM) and inhibits bacterial growth under conditions that compromise the cell envelope. |
| PC-47010 |
TXY436
FtsZ inhibitor
|
TXY436 is an N-Mannich base derivative and FtsZ-directed prodrug of PC190723, TXY436 is effective against S. aureus can also target Gram-negative bacteria, such as Escherichia coli. |
