Cat. No. |
Product Name |
Information |
PC-61940 |
GSK-229423
Bacterial DNA gyrase inhibitor
|
GSK-229423 is a novel bacterial topoisomerase inhibitor that shows potent inhibition of supercoiling by DNA gyrase from S. aureus with IC50 of 14 nM. |
PC-61939 |
NXL101
Bacterial DNA gyrase inhibitor
|
NXL101 is a novel quinoline bacterial DNA gyrase and topoisomerase IV inhibitor that shows potent activity against gram-positive bacteria, including methicillin- and fluoroquinolone-resistant strains. |
PC-61938 |
GSK-2140944
Bacterial Topo II inhibitor
|
GSK-2140944 (Gepotidacin) is a novel potent, selective bacterial type II topoisomerase inhibitor in development for the treatment of conventional and biothreat pathogens, including Gram-positive pathogens and MRSA. |
PC-61783 |
Inh2-B1
STK1 inhibitor
|
Inh2-B1 (STK1 inhibitor B1) is a novel specific S aureus Ser/Thr protein kinase (STK1) inhibitor with IC50 of 49 uM, directly binds to ATP-binding catalytic domain. |
PC-61756 |
NITD-304
MmpL3 inhibitor
|
NITD-304 is a novel, orally bioavailable mycobacterial membrane protein Large 3 (MmpL3) inhibitor with MIC of 15 nM against M tuberculosis H37Rv. |
PC-61751 |
AU-1235
MmpL3 inhibitor
|
AU-1235 is a novel, specific mycobacterial membrane protein large 3 (MmpL3) inhibitor with MIC of 0.1 ug/mL (0.3 uM) against Mtb H37Rv.. |
PC-61388 |
Macozinone
|
Macozinone (PBTZ-169, PBTZ169) is a potent, second-generation antituberculosis agent that inhibits DprE1 and displays nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro. |
PC-61371 |
Contezolid
|
Contezolid (MRX I) is an orally active oxazolidinone agent with antibacterial activity Gram-positive pathogens, including MRSA, penicillin-PRSP, PISP, and vancomycin-resistant enterococci (VRE) with MIC of 0.25-4 ug/mL. |
PC-61295 |
Murepavadin
Antibiotic, MRGPRX2 agonist
|
Murepavadin (POL7080) is a highly potent, specific, macrocycle Pseudomonas antibiotic, activates mast cells via MRGPRX2 and MrgprB2. |
PC-61266 |
KKL-40
|
A small-molecule inhibitor of bacterial ribosome rescue that exhibits broad-spectrum antimicrobial activity against bacteria grown in liquid culture. |
PC-61265 |
KKL-10
|
KKL-10 is a small-molecule inhibitor of bacterial ribosome rescue that exhibits broad-spectrum antimicrobial activity against bacteria grown in liquid culture. |
PC-70341 |
DSM 74
Pf DHODH inhibitor
|
DSM 74 is a potent, orally active PfDHODH inhibitor (IC50=0.3 uM) with antimalarial activity. |