| Cat. No. |
Product Name |
Information |
| PC-49748 |
HSK16149
VGCC α2δ ligand
|
HSK16149 (HSK 16149) is a potent selective ligand of voltage-gated calcium channel (VGCC) α2δ subunit with IC50 of 3.96 nM in competitive [3H]gabapentin binding assays. |
| PC-47015 |
2E151
Calcium channel activator
|
2E151 is a small molecule calcium channel activator, increases murine antigen-specific antibody responses when used as a co-adjuvant with LPS. |
| PC-47014 |
2D216
Calcium channel activator
|
2D216 is a small molecule calcium channel activator, increases murine antigen-specific antibody responses when used as a co-adjuvant with LPS. |
| PC-38485 |
VK-II-86
RyR2 inhibitor
|
VK-II-86 is a carvedilol analogue lacking antagonist activity at β-adrenoceptors, effectively suppresses SOICR by directly reducing the open duration of the cardiac ryanodine receptor (RyR2). |
| PC-38432 |
Zegocractin
Orai1 channel inhibitor
|
Zegocractin (CM4620) is a selective small molecule Orai1 channel inhibitor, inhibits Orai1/STIM1-mediated Ca2+ currents and Orai2/STIM1-mediated currents with IC50 of 120 nM and 900 nM, respectively. |
| PC-72456 |
RyR1 inhibitor compound 1
RyR1 inhibitor
|
RyR1 inhibitor compound 1 is a potent, RyR1-selective inhibitor, inhibits the RyR1 channel with IC50 of 12 nM in HEK293 cell-based assay. |
| PC-38082 |
Etripamil
Calcium channel blocker
|
Etripamil (MSP-2017) is a novel intranasal non-dihydropyridine calcium channel blocker that has begun phase III clinical trials for the treatment of paroxysmal supraventricular tachycardias.. |
| PC-35727 |
BTT-369
Cav2.2 inhibitor
|
BTT-369 (BTT369) is a voltage-gated CaV2.2 calcium channel inhibitor that disrupts the CaVα·CaVβ3 protein-protein interaction with Ki of 2.0 uM in FP assays. |
| PC-35726 |
BTT-266
Cav2.2 inhibitor
|
BTT-266 (BTT266) is a voltage-gated CaV2.2 calcium channel inhibitor that disrupts the CaVα·CaVβ3 protein-protein interaction, directly binds to CaVβ3 with Kd of 3.6 uM. |
| PC-35299 |
CDN1163
SERCA2 activator
|
CDN1163 (CDN-1163) is a small molecule, allosteric activator of SERCA2, dose-dependently increases the Vmax of SERCA2 Ca2+-ATPase activity in ER microsomes. |
| PC-63469 |
RU1968
CatSper inhibitor
|
RU1968 is a potent, cross-species sperm-specific Ca2+ channel CatSper inhibitor that is selective for CatSper over Slo3. |
| PC-63281 |
JTV-519
SERCA inhibitor
|
JTV-519 (K201) is a Ca2+-dependent blocker of SERCA and a partial agonist of ryanodine receptors (RyRs). |
