| Cat. No. |
Product Name |
Information |
| PC-60961 |
YKL-1-116
CDK7 inhibitor
|
YKL-1-116 is a potent, selective and covalent inhibitor of CDK7 that does not inhibit other CDKs. |
| PC-60893 |
BRD6989
CDK8 inhibitor
|
BRD6989 is a potent, selective CDK8 inhibitor with IC50 of 0.5 uM against recombinant Cyclin C/CDK8 complex. |
| PC-60582 |
(R)-DRF053 dihydrochloride
CK1/CDK inhibitor
|
(R)-DRF053 dihydrochloride (DRF053) is a potent, cell-permeable, dual CK1/CDK inhibitor with IC50 of 14 nM, 220 nM and 80 nM for CK1, CDK5/p25 and CDK1/cyclin B, respectively. |
| PC-60539 |
BAY-958
CDK9 inhibitor
|
BAY-958 (BAY958, LDC526) is a potent, selective PTEFb/CDK9 inhibitor with IC50 of 5 nM against CDK9/CyclinT1. |
| PC-60537 |
Atuveciclib
CDK9 inhibitor
|
Atuveciclib (BAY-1143572) is a potent, highly selective, orally bioavailable CDK9/P-TEFb inhibitor with IC50 of 6 nM for CDK9/CyclinT1. |
| PC-60490 |
CDK12 inhibitor E9 S-isomer
|
CDK12 inhibitor E9 S-isomer (E9, CDK12-IN-E9) is a clinical analog of THZ1 and a selective, covalent CDK12 inhibitor that is not susceptible to ABC transporter-mediated drug efflux. |
| PC-60398 |
G1T38 dihydrochloride
CDK4/6 inhibitor
|
Lerociclib (G1T38) dihydrochloride is a potent and selective inhibitor of CDK4/6 with biochemical IC50 of 1 nM and 2 nM for CDK4/cyclin D1 and CDK6/cyclin D3, respectively. |
| PC-60397 |
G1T38
CDK4/6 inhibitor
|
G1T38 (Lerociclib, G1T 38) is a novel, potent and selective inhibitor of CDK4/6 with biochemical IC50 of 1 nM and 2 nM for CDK4/cyclin D1 and CDK6/cyclin D3, respectively. |
| PC-60395 |
Trilaciclib
CDK4/6 inhibitor
|
Trilaciclib (G1T28) is a novel, potent and selective inhibitor of CDK4/6 with biochemical IC50 of 1 nM and 4 nM for CDK4/cyclin D1 and CDK6/cyclin D3, respectively. |
| PC-60329 |
NVP-2
CDK9 inhibitor
|
NVP-2 is a potent, selective, ATP-competitive CDK9 inhibitor with IC50 of <0.514 nM (CDK9/CyclinT). |
| PC-70170 |
GW-8510
CDK2 inhibitor
|
GW-8510 (GW8510) is a potent, selective inhibitor of CDK2 with IC50 of 10 nM. |
| PC-70116 |
NU-6027
CDK1/2 inhibitor
|
NU-6027 (NU6027) is an ATP-competitive inhibitor of CDK1 and CDK2 with Ki of 2.5 uM and 1.3 uM respectively. |
