| Cat. No. |
Product Name |
Information |
| PC-49195 |
NSC373981
CARD11 G4 stabilizer
|
NSC373981 (NSC 373981) is a CARD11 G-quadruplex (G4) stabilizing small molecule that downregulates CARD11 gene expression in DLBCL cells. |
| PC-49169 |
QBS10072S
Alkylating agent
|
QBS10072S is a novel dual-function, BBB permeable chemotherapeutic agent with alkylating moiety and a selective large neutral amino acid transporter 1 (LAT1, SLC7A5) substrate, shows excellent BBB penetration and promising efficacy in vitro (U251 cell IC50=12 uM) and in vivo against glioblastoma (GBM). |
| PC-38759 |
AST-3424 (S-isomer)
DNA alkylating agent
|
OBI-3424 S-isomer (TH-3424, OBI 3424) is a highly potent DNA alkylating prodrug that is converted by AKR1C3 to a potent DNA-alkylating agent. |
| PC-35531 |
OBI-3424
|
OBI-3424 (AST-3424, TH-3424) is a first-in-class, novel prodrug that selectively targets cancers overexpressing the enzyme AKR1C3, OBI-3424 is a highly selective prodrug that is converted by AKR1C3 to a DNA alkylating agent. |
| PC-60562 |
Melflufen
|
Melflufen (Melphalan flufenamide, J1) is a novel dipeptide and alkylating prodrug of melphalan, inhibits angiogenesis in vitro and in vivo. |
| PC-45362 |
Thio-TEPA
|
An alkylating agent used to treat cancer that has been previously used in the palliation of a wide variety of neoplastic diseases.. |
| PC-45183 |
Temozolomide
|
An alkylating agent used as a treatment of some brain cancers, astrocytoma and glioblastoma. |
| PC-45242 |
Cyclophosphamide hydrate
|
A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. |
| PC-45241 |
Cyclophosphamide
|
A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. |
| PC-42280 |
Bisantrene
|
A small molecule DNA intercalater with antineoplastic activity, does not exhibit cardiotoxicity compared with doxorubicin. |
| PC-42644 |
Evofosfamide
|
A potent and selective hypoxia-activated phosphoramidate DNA cross-linking mustard. |
| PC-45193 |
Oxaliplatin
|
A platinum-based antineoplastic agent that works by blocking the duplication of DNA. |
