| Cat. No. |
Product Name |
Information |
| PC-22121 |
VVD-214
WRN inhibitor
|
VVD-214 (VVD214) is a potent, selective, covalent allosteric inhibitor of WRN helicase, covalently engages cysteine 727 of WRN in a nucleotide cooperative manner and inhibits ATP hydrolysis and helicase activity. |
| PC-21006 |
H3B-968
WRN helicase inhibitor
|
H3B-968 is a potent, selective and covalent inhibitor of Werner syndrome protein (WRN) helicase activity with IC50 of 41 and 13 nM in ADP-Glo assay DNA unwinding assay, respectively. |
| PC-21005 |
H3B-960
WRN helicase inhibitor
|
H3B-960 is a potent, selective and covalent inhibitor of Werner syndrome protein (WRN) helicase activity with IC50 of 60 nM. |
| PC-20997 |
AOH1996
PCNA inhibitor
|
AOH1996 (AOH-1996) is a small molecule, orally active inhibitor of cancer-associated isoform of proliferating cell nuclear antigen (caPCNA), exerts potent, selective anticancer effects. |
| PC-20677 |
Werner syndrome RecQ helicase-IN-4
WRN inhibitor
|
Werner syndrome RecQ helicase-IN-4 is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor with IC50 of 60 nM for WRN ATPase. |
| PC-20676 |
Werner syndrome RecQ helicase-IN-3
WRN inhibitor
|
Werner syndrome RecQ helicase-IN-3 is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor with IC50 of 60 nM for WRN ATPase. |
| PC-20675 |
Werner syndrome RecQ helicase-IN-2
WRN inhibitor
|
Werner syndrome RecQ helicase-IN-2 is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor with IC50 of 100 nM for WRN ATPase. |
| PC-20674 |
HRO761
WRN inhibitor
|
HRO761 (HRO-761) is the first potent and selective, allosteric inhibitor of RecQ DNA helicase WRN with IC50 of 50 nM, shows potent and selective anti-tumor activity in cancers with microsatellite instability. |
| PC-49111 |
SU0448
MTH1 activator
|
SU0448 is a specific, cell-permeable small molecule activator of the DNA repair enzyme Human MutT Homolog 1 (MTH1) with AC50 value of 5.5 uM, inhibits cell viability of HCC1806 cells with IC50 of 36.1 uM. |
| PC-72920 |
T2AA
PCNA inhibitor
|
T2AA (T2 amino alcohol) is a small molecule proliferating cell nuclear antigen (PCNA) inhibitor, inhibits interaction of PCNA/PIP-box peptide with IC50 of 1 uM. |
| PC-72025 |
SU0383
OGG1-MTH1 inhibitor
|
SU0383 (SU 0383) is a potent, dual inhibitor of repair enzyme OGG1 and NUDT1 (MTH1) with IC50 of 34 nM and 490 nM, respectively. |
| PC-35806 |
TH5487
OGG1 inhibitor
|
TH5487 (TH-5487, TH 5487) is a potent, selective, active-site inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1) with IC50 of 342 nM, prevents OGG1 from binding to its DNA substrate. |
