| Cat. No. |
Product Name |
Information |
| PC-62772 |
MRK-696
|
MRK-696 is a non-selective benzodiazepine receptor partial agonist.. |
| PC-62769 |
TPA023
|
TPA023 is a potent, α2/α3 subtype-selective, and oral GABAA receptor agonist with Kd of 0.92, 1.05 and 0.58 nM for α1-, α2-, α3-, and α5-containing human receptors. |
| PC-62765 |
AZD6280
|
AZD6280 is a potent, α2/3 functionally selective, partial GABAA receptor modulator with pKi of 7.7. |
| PC-62764 |
Lesogaberan
|
Lesogaberan (AZD-3355) is a potent, selective, peripherally acting GABAB receptor agonist with Ki of 5 nM and EC50 of 8.6 nM, 274-fold selectivity over GABAA (Ki=1.4 uM). |
| PC-62759 |
CPP-115
|
CPP-115 is an orally available, small molecule, next-generation GABA aminotransferase (GABA-AT) inhibitor with Ki of 31 uM, without other GABAergic or off-target activities. |
| PC-62625 |
PWZ-029
|
PWZ-029 is a potent, subtype-selective partial inverse agonist of α5 GABAA receptors with Ki of 30 nM, demonstrates memory enhancing effects in vivo. |
| PC-62099 |
DCBS152A
|
DCBS152A is a potent, functionally selectiver negative modulator of GABAA receptor at the modulatory PQ site in some receptor isoforms.. |
| PC-62091 |
MK-0343
|
MK-0343 (MRK-409) is a potent, α2/3 subtype selective, partial GABAA receptor agonist, shows greater agonist efficacy at the α3 over α1 subtypes. |
| PC-62090 |
AZD-7325
|
AZD-7325 is a potent, α2/3 functionally selective, partial GABAA receptor modulator with pKi of 9.51. |
| PC-60203 |
PPT
|
An allosteric GABAA receptor modulator that strongly suppresses GABA-induced chloride currents.. |
| PC-42797 |
NS11394
|
A potent, subtype-selective, orally available GABAA receptor positive modulator with Ki of 0.4, 0.8, 0.5 and 0.1 nM for α1, α2, α3 and α5 subunits together with β3γ2. |
| PC-42414 |
Pagoclone
|
A potent, orally active GABAA receptor agonist with high affinity (0.7-9.1nM) to the benzodiazepine binding site of GABAA receptors containing either an α1, α2, α3 or α5 subunit. |
