| Cat. No. |
Product Name |
Information |
| PC-60309 |
Ruzasvir
HCV NS5A inhibitor
|
Ruzasvir (MK-8408) is a potent, pan-genotype HCV NS5A inhibitor with replicon EC90 of 0.003, 0.016, 0.067, 0.036, 0.007, and 0.007 nM for GT1a, GT1a L31V, GT1a Y93H, GT2b, GT3a, and Gt4a, respectively. |
| PC-60009 |
INX-08189
HCV NS5B inhibitor
|
INX-08189 (BMS-986094) is a phosphoramidate prodrug of O-6-methyl-2-C-methyl guanosine, potent inhibitor of HCV NS5B polymerase with IC50 of 10 nM in replicon assay. |
| PC-42412 |
PSI-6130
|
PSI-6130 (R-1656) is a potent, specific inhibitor of HCV RNA synthesis by inhibiting the NS5B RNA polymerase (EC90=4.6 uM in replicon assay). |
| PC-42604 |
Daclatasvir
HCV NS5A inhibitor
|
Daclatasvir (BMS-790052) is a potent HCV NS5A inhibitor with EC50 of <50 pM against genotype 1 replicons. |
| PC-42605 |
NM107
HCV NS5B inhibitor
|
NM107 (Valopicitabine) is a nucleoside inhibitor of HCV NS5B polymerase with EC50 of 1.23 uM against HCV 1b replicon cells. |
| PC-21356 |
Sofosbuvir
HCV NS5B inhibitor
|
Sofosbuvir (GS-7977, PSI-7977) is a prodrug of 2'-F-2'-C-methyluridine monophosphate and HCV NS5B polymerase inhibitor, is active against GT 1a, 1b, and 2a (strain JFH-1) replicons and chimeric replicons containing GT 2a (strain J6), 2b, and 3a NS5B polymerase. |
| PC-21355 |
Dasabuvir
HCV NS5B inhibitor
|
Dasabuvir (ABT-333) is a potent, selective, and nonnucleoside inhibitor of HCV NS5B polymerase with IC50 of 2.2-10.7 nM for HCV genotype 1a and 1b. |
| PC-21354 |
Ledipasvir
HCV NS5A inhibitor
|
Ledipasvir (GS-5885) is a potent, selective and oral HCV NS5A inhibitor with EC50 of 31 pM and 4 pM against GT1a and GT1b, respectively. |
| PC-21353 |
Elbasvir
HCV NS5A inhibitor
|
Elbasvir (MK-8742) is a potent, tetracyclic indole-based HCV NS5A inhibitor, shows broad HCV genotype activity with IC50 of 0.003, 0.003, 0.004, 0.5, 2.4 nM for genotype 1b, 2a, 1a, 1aL31V and 1aY93H, respectively. |
| PC-21352 |
Ombitasvir
HCV NS5A inhibitor
|
Ombitasvir (ABT-267) is a potent, selective pan-genotypic inhibitor of HCV NS5A with EC50 of 1.7-19.3 pM against GT1a, -1b, -2a, -2b, -3a, -4a, and -5a and 366 pM against GT6a. |
| PC-20275 |
Nesbuvir
HCV NS5B inhibitor
|
Nesbuvir (HCV-796) is a selective, non-nucleoside HCV nonstructural protein 5B (NS5B) polymerase inhibitor with IC50 of 0.01-0.14 uM for genotype 1, EC50 of 5 nM and 9 nM against genotype 1a and 1b replicon. |
| PC-72397 |
GSK2818713
HCV NS5A inhibitor
|
GSK2818713 (GSK-2818713) is a nonstructural protein 5A (NS5A) HCV inhibitor with broad genotype coverage. |
