Cat. No. |
Product Name |
Information |
PC-21407 |
YAK540
class IIa HDAC inhibitor
|
YAK540 is a potent, highly selective class IIa HDAC inhibitor with IC50 of 114 nM (HDAC4), displays excellent selectivity against HDAC2 (265-fold), HDAC6 (100-fold), and HDAC8 (82-fold). |
PC-21403 |
HDAC11 inhibitor PB94
HDAC11 inhibitor
|
HDAC11 inhibitor PB94 is a potent, selective and brain-permeable HDAC11 inhibitor with IC50 of 108 nM, >40-fold over other HDAC isoforms. |
PC-21394 |
PB118
HDAC6 inhibitor.
|
PB118 is a potent, selective HDAC6 inhibitor with IC50 of 5.6 nM, shows >1000 times selectively towards HDAC1, reduces alzheimer's disease neuropathology. |
PC-21309 |
KPZ560
HDAC1/2 inhibitor
|
KPZ560 is a potent, HDAC1/2-selective inhibitor with IC50 of 12/68 nM, respectively. |
PC-21304 |
Mz325
Sirt2/HDAC6 inhibitor
|
Mz325 is a potent, selective, dual inhibitor of Sirt2/HDAC6 with IC50 of 320/43 nM, respectively. |
PC-21115 |
HDAC3 inhibitor 4i
HDAC3 inhibitor
|
HDAC3 inhibitor 4i is a potent, selective HDAC3 inhibitor with IC50 of 14 nM, shows 121-fold selectivity over HDAC1 (IC50=1983 nM) and HDAC2 (IC50=1696 nM). |
PC-21042 |
KD5170
Class I /II HDAC inhibitor
|
KD5170 (KD-5170) is a potent mercaptoketone-based Class I and II-histone deacetylase (HDAC) inhibitor with IC50 of 45 nM in HeLa cell-based histone H3 hyperacetylation assay. |
PC-20984 |
Citarinostat
HDAC6 inhibitor
|
Carinostat (ACY-241) is a second generation potent, orally active and high-selective HDAC6 inhibitor with IC50 of 2.6 nM. |
PC-20913 |
Givinostat hydrochloride monohydrate
pan HDAC inhibitor
|
Givinostat (ITF-2357) is a potent, orally active, pan-HDAC inhibitor with IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. |
PC-20784 |
Romidepsin
HDAC inhibitor
|
Romidepsin (FK228, NSC 63017, R 901228, Depsipeptide) is a natrual produrct from Chromobacterium violaceum as class I HDACs inhibitor, inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC50s of 36 nM, 47 nM, 510 nM and 1400 nM, respectively. |
PC-20671 |
TNG260
CoreDAC inhibitor
|
TNG260 (TNG-260) is a potent, CoREST-selective deacetylase (CoreDAC) inhibitor, inhibits HDAC1 with 10-fold selectivity over HDAC3 in cells. |
PC-20479 |
Purinostat
Class I /IIb HDAC inhibitor
|
Purinostat is a potent, highly selective class I and IIb HDAC inhibitor with IC50 of 0.81, 1.4, 1.7, and 3.8 nM for class I HDAC1, 2, 3, and 8, and 11.5, 1.1 nM for class IIb HDAC 6 and 10, respectively. |