Cat. No. |
Product Name |
Information |
PC-72737 |
Belzutifan
HIF2α inhibitor
|
Belzutifan (PT2977, MK-6482) is a potent and selective small-molecule inhibitor of HIF2α with SPA IC50 of 9 nM, EC50 of 11 nM (HIF-2α luciferase assay). |
PC-72705 |
KUSC-5037
HIF-1 inhibitor
|
KUSC-5037 (KUSC5037) is a novel effective HIF-1 inhibitor with IC50 of 1.2 uM against HIF-1 transcriptional activity. |
PC-72329 |
Arylsulfonamide 64B
HIF inhibitor
|
Arylsulfonamide 64B (HIF inhibitor 64B) is a small molecule inhibitor of HIF pathway, blocks hypoxia-induced expression of c-Met and CXCR4 and uveal melanoma (UM) cell migration. |
PC-38083 |
Izilendustat
HIF-PHD inhibitor
|
Izilendustat is a potent inhibitor of HIF prolyl hydroxylase (PHD) which stabilizes hypoxia inducible factor- 1 alpha (HIF- lα), as well as hypoxia inducible factor-2 (HIF-2).. |
PC-43531 |
Roxadustat
HIF-PHD inhibitor
|
Roxadustat (FG4592, FG-4592) is a potent, orally available HIF prolyl hydroxylase (HIF-PHD) with IC50 of 591.4 nM. |
PC-44597 |
FG-2216
HIF-PHD inhibitor
|
FG-2216 (YM-311, IOX3) is a potent, selective small molecule inhibitor of HIF prolyl hydroxylase (HIF-PHD) with IC50 of 3.9 nM (PHD2). |
PC-43140 |
Molidustat
HIF-PHD inhibitor
|
Molidustat (BAY 85-3934) is an orally active small molecule inhibitor of hypoxia inducible factor prolyl hydroxylase (HIF-PHD) with IC50 of 480 nM, 280 nM and 450 nM for PHD1, PHD2, and PHD3, respectively. |
PC-62044 |
KHS-101
|
KHS-101 (KHS101) is a small molecule that selectively induces a neuronal differentiation phenotype, induces neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs) by interacting with TACC3 (EC50=1 uM). |
PC-61213 |
JNJ-42905343
|
JNJ-42905343 is a potent, selective, orally active prolyl hydroxylase (PHD) inhibitor with pKi of 8.07, 7.48 and 7.27 for PHD1, PHD2 and PHD3 respectively. |
PC-60509 |
Desidustat
|
Desidustat (ZYAN1) is a novel HIF prolyl hydroxylase (PHD) inhibitor under clinical development for the treatment of anemia. |
PC-60370 |
IDF-11774
HIF-1α inhibitor
|
IDF-11774 (IDF 11774, IDF11774) is a potent, orally bioavailable HIF-1 inhibitor that reduces the HRE-luciferase activity of HIF-1α (IC50=3.65 uM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells. |
PC-60317 |
PT-2399
|
PT-2399 (PT 2399, PT2399) is a selective, potent HIF-2α antagonist that binds directly to the HIF2α PAS B domain. |