| Cat. No. |
Product Name |
Information |
| PC-60148 |
JTZ-951 hydrochloride
HIF-PHD inhibitor
|
Enarodustat hydrochloride (JTZ-951 hydrochloride) is a novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2. |
| PC-60147 |
JTZ-951
HIF-PHD inhibitor
|
Enarodustat (JTZ-951) is a novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2. |
| PC-45660 |
THS-044
|
THS-044 is a low micromolar HIF2α PAS-B binding compound (Kd=2 uM). |
| PC-45555 |
KC7F2
|
KC7F2 is a small molecule HIF-1α translation inhibitor with IC50 of 20 uM. |
| PC-42474 |
PX-478
HIF-1α inhibitor
|
PX-478 is a potent, selective inhibitor of HIF-1α and HIF-1 transcription factor activity. |
| PC-45759 |
HIF2α-IN-1
|
A potent HIF-2α inhibitor with IC50 of <500 nM in HIF-2α scintillation proximity assay. . |
| PC-42346 |
Vadadustat
HIF-PHD inhibitor
|
Vadadustat (PG-1016548, AKB-6548) is a novel, potent, orally active HIF prolyl-4-hydroxylase (HIF-PHD) inhibitor with pKi of for PHD1, PHD2, and PHD3, respecitvely. |
| PC-42229 |
SYP-5
|
A novel potent HIF-1 inhibitor that inhibits hypoxia-induced upregulation of HIF-1, suppresses tumor cells invasion and angiogenesis. |
| PC-45387 |
Daprodustat
HIF-PHD inhibitor
|
Daprodustat (GSK1278863) is a potent, orally active HIF-prolyl hydroxylase (PHD) inhibitor with IC50 of 3.5, 22.2 and 2.2 nM for PHD1, PHD2 and PHD3, respectively. |
| PC-21729 |
FG-0041
HIF-PH inhibitor
|
FG-0041 (FG0041) is a small molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with IC50 of 2 uM for collagen prolyl hydroxylase. |
| PC-21420 |
MO-2097
hnRNPA2B1 inhibitor
|
MO-2097 is a small molecule hnRNPA2B1-binding compound (ITC KD=43.1 uM) that suppresses hnRNPA2B1-induced HIF-1α protein expression under hypoxic and mimetic hypoxia. |
| PC-20456 |
ER-400583-00
HIF-1α inhibitor
|
ER-400583-00 is a small-molecule HIF-1α inhibitor, inhibits the induction of HIF-1 reporter activity in response to hypoxia with IC50 of 7.9 nM. |
