| Cat. No. |
Product Name |
Information |
| PC-21297 |
BX-2819
HSP90 inhibitor
|
BX-2819 is a potent, selective Hsp90 inhibitor with KD of 16.4 nM for human Hsp90α, also is a potent B. burgdorferi high-temperature protein G (Bb HtpG) with KD of 12 nM. |
| PC-21226 |
EC144
HSP90 inhibitor
|
EC144 (EC-144) is a potent, second generation inhibitor of heat shock protein 90 (Hsp90) with IC50 of 1.1 nM in Hsp90α binding assay, degrades Her-2 in MCF-7 cells with EC50 of 14 nM. |
| PC-21200 |
NVP-HSP990
HSP90 inhibitor
|
NVP-HSP990 (HSP990) is a potent, selective, oral and brain-penetrant Hsp90 inhibitor with IC50 of 0.6, 0.8 and 8.5 nM for Hsp90α, Hsp90β and Grp94, respectively. |
| PC-20710 |
STA-9090
HSP90 inhibitor
|
Ganetespib (STA 9090) is a potent, second generation small-molecule inhibitor of HSP90 (IC50=4 nM). |
| PC-20709 |
STA-1474
HSP90 inhibitor
|
STA-1474 is a water soluble prodrug of Ganetespib (STA 9090), which is a potent, second generation small-molecule inhibitor of HSP90 (IC50=4 nM). |
| PC-20637 |
Foldlin
HSF-1 activator
|
Foldlin is a small-molecule tool compound that reduces the protein levels of misfolded/aggregated mutant p53, without effect on contact mutants or wild-type p53, Foldlin is small-molecule HSF-1 activator. |
| PC-20551 |
SOMCL-16-175
Hsp90α modulator
|
SOMCL-16-175 is a non-covalent, allosteric modulator targeting Hsp90α’s middle domain (Hsp90M) with binding Kd of 804 uM, inhibits breast cancer cell growth and proliferation. |
| PC-49842 |
PST inhibitor peptide-8
Pancreastatin inhibitor
|
PST inhibitor peptide-8 (PSTi8) is a potent pancreastatin (PST) inhibitor, competes with PST on GRP78 receptor binding and rescues PST-induced insulin resistance (IR) both in vitro and in vivo. |
| PC-49775 |
KUNG65
Grp94 inhibitor
|
KUNG65 is a potent, selective glucose regulated protein 94 (Grp94) inhibitor with Kd value of 540 nM in fluorescence polarization assays, 73-fold selectivity over Hsp90α. |
| PC-49670 |
VER-50589
Hsp90 inhibitor
|
VER-50589 (VER50589) is a potent, selective small-molecule inhibitor of Hsp90 with IC50 of 21 nM and Kd value of 4.5 nM. |
| PC-49669 |
VER-49009
Hsp90 inhibitor
|
VER-49009 (CCT0129397, VER49009) is a potent, selective small-molecule inhibitor of Hsp90 with IC50 of 25 nM and Kd value of 78 nM, inhibits ATPase activity of full length yeast Hsp90 protein with IC50 of 0.14 uM. |
| PC-49601 |
Grp78 inhibitor 8
Grp78 inhibitor
|
Grp78 inhibitor 8 is a potent, isoform-selective inhibitor of the ER Resident Chaperone Grp78. |
