| Cat. No. |
Product Name |
Information |
| PC-49040 |
HhAg1.5
Hedgehog agonist
|
HhAg1.5 (SAg1.5) is a small molecule Hedgehog agonist with EC50 of 1 nM, induces cilia translocation of SMO and GLI transcription factor activation, efficiently generates expandable liver stem cells (LSCs) in vitro. |
| PC-49012 |
MDB5
Hh pathway inhibitor
|
MDB5 is a potent hedgehog (Hh) signaling pathway inhibitor, exhibits stronger inhibition of the Hh pathway and anticancer effect in vitro and vivo than GDC-0449. |
| PC-72867 |
Rhonin
RHOGDI1 inhibitor
|
Rhonin is the first small-molecule ligand of the RHO GDP-dissociation inhibitor 1 (RHOGDI1), binds to RHOGDI (Ki=2.2 uM), is an inhibitor of Hh-induced osteogenesis. |
| PC-62852 |
BRD9526
Shh inhibitor
|
BRD9526 is a potent, small-molecule inhibitor of the Sonic Hedgehog (Shh) pathway with EC50 of 60 nM, partially lowers Gli1 expression at concentrations of 10 uM, a useful probe of Shh signaling pathway. . |
| PC-62851 |
BRD50837
Hedgehog inhibitor
|
BRD50837 is a potent, selective, small-molecule inhibitor of the Sonic Hedgehog (Shh) pathway with EC50 of 90 nM, partially lowers Gli1 expression at concentrations of 2 uM, a useful probe of Shh signaling pathway. . |
| PC-62179 |
HPI-1
Hedgehog inhibitor
|
HPI-1 is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Shh (IC50=1.5 uM) without significantly affecting Wnt signaling (IC50>30 uM). |
| PC-60477 |
TAK-441
Hedgehog inhibitor
|
TAK-441 is a highly potent, orally active hedgehog signaling (Hh) inhibitor with IC50 of 4.4 nM in Gli-luc reporter assays. |
| PC-70165 |
RUSKI-201
Hedgehog acyltransferase inhibitor
|
RUSKI-201 is a potent, selective and cell active Hedgehog acyltransferase (Hhat) inhibitor with IC50 of 0.87 uM. |
| PC-45464 |
RU-SKI 43 hydrochloride
Hedgehog acyltransferase inhibitor
|
RU-SKI 43 hydrochloride is a small molecule inhibitor of Hhat (Hedgehog acyltransferase) with IC50 of 0.85 uM. |
| PC-45463 |
RU-SKI 43
Hedgehog acyltransferase inhibitor
|
RU-SKI 43 is a small molecule inhibitor of Hhat (Hedgehog acyltransferase) with IC50 of 0.85 uM. |
| PC-42258 |
Ciliobrevin A
|
A small molecule Hedgehog pathway inhibitor (IC50=7 uM) that acts downstream of Su(fu) to modulate Gli processing, activation or trafficking. |
| PC-45147 |
Cyclopamine
|
A natural steroidal alkaloid that inhibits hedgehog (Hh) signaling with IC50 of 46 nM. |
