| Cat. No. |
Product Name |
Information |
| PC-20352 |
EPZ020809
KDM4C inhibitor
|
EPZ020809 is a potent, specific KDM4C inhibitor with Ki of 31 nM, binds KDM4C in a 2-OG-competitive fashion. |
| PC-49236 |
FTO-43
FTO inhibitor
|
FTO-43 (FTO-43 N) is a potent, selective inhibitor of the m6A demethylase fat mass- and obesity-associated protein (FTO) with IC50 of 1.0 uM, no significant acitivity against the homologous m6A RNA demethylase ALKBH5 (IC50>40 uM). |
| PC-38672 |
Pulrodemstat besylate salt
LSD1 inhibitor
|
Pulrodemstat (CC-90011) is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with biochemical IC50 of 0.3 nM. |
| PC-38671 |
Pulrodemstat
LSD1 inhibitor
|
Pulrodemstat (CC-90011) is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with biochemical IC50 of 0.3 nM. |
| PC-38508 |
GSK-J1
KDM6A/6B inhibitor
|
GSK-J1 is a potent, selective inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A) with IC50 of 28 nM and 53 nM, respectively. |
| PC-72834 |
JIB-04
Jumonji inhibitor
|
JIB-04 is a pan-Jumonji histone demethylase inhibitor (IC50=230-1100 nM) with epigenetic activity, also potently inhibits SARS-CoV-2 replication in Vero E6 cells with EC50 of 695 nM. |
| PC-72453 |
KDOBA67
KDM6A/B inhibitor
|
KDOBA67 is a novel cell-permeable inhibitor of H3K27 lysine demethylase KDM6A/B, inhibits TBXT expression chordoma cell lines. |
| PC-72386 |
MO-I-500
FTO inhibitor
|
MO-I-500 is a pharmacological inhibitor of FTO, inhibits purified FTO demethylase catalyzing demethylation with IC50 of 8.7 uM. |
| PC-72265 |
SKLB325
JMJD6 inhibitor
|
SKLB325 (SKLB 325) is a potential inhibitor for JMJD6 with Kd of 0.755 uM by SPR assays, biochemical IC50 of 0.78 uM. |
| PC-72264 |
JMJD7 inhibitor compound 3 (Cpd-3)
JMJD7 inhibitor
|
JMJD7 inhibitor compound 3 (Cpd-3) is the first small molecule inhibitor of JMJD7 with IC50 of 6.62 uM, efficiently bind to JMJD7 in vitro, displays good inhibitory activity against cancer cell lines expressing a high level of JMJD7. |
| PC-72263 |
MINA53 inhibitor 10
MINA53 inhibitor
|
MINA53 inhibitor 10 is a first in class, potent, selective MINA53 inhibitor with IC50 of 1.5 uM, selective over NO66, KDM4-6 and other JmjC oxygenases. |
| PC-72262 |
MINA53 inhibitor 9
MINA53 inhibitor
|
MINA53 inhibitor 9 is a first in class, potent, selective MINA53 inhibitor with IC50 of 1.6 uM, selective over NO66, KDM4-6 and other JmjC oxygenases. |
