| Cat. No. |
Product Name |
Information |
| PC-70107 |
EPZ-030456
|
EPZ-030456 (EPZ030456) is a potent, selective SMYD3 inhibitor with biochem IC50 of 4 nM. |
| PC-70104 |
MM-589
MLL1/WDR5 inhibitor
|
A highly potent, cell-permeable inhibitor of WDR5-MLL interaction with IC50 of 0.9 nM, Ki of <1 nM. |
| PC-60300 |
MS-453
SETD8 inhibitor
|
MS-453 (MS453) is a potent, selective and covalent protein lysine methyltransferase SETD8 inhibitor with IC50 of 804 nM. |
| PC-60299 |
CPI-1205
|
Lirametostat (CPI-1205) is a highly potent, selective EZH2 inhibitor with biochemical IC50 of 2 nM, cellular EC50 of 32 nM. |
| PC-60263 |
JQEZ5
EZH2 inhibitor
|
JQEZ5 (JQ5, EZ005) is a novel potent, selective, SAM-competitive EZH2 inhibitor with IC50 of 80 nM (inhibition of enzymatic function of PRC2). |
| PC-60256 |
CM-579
|
CM-579 (CM579) is a novel potent, selective and reversible dual inhibitor of G9a/DNMTs with IC50 of 16 nM and 32 nM for G9a and DNMT1, respectively. |
| PC-60255 |
CM-272
G9a inhibitor
|
CM-272 (CM272) is a novel potent, selective and reversible dual inhibitor of G9a/DNMTs with IC50 of 8 nM and 382 nM for G9a and DNMT1, respectively. |
| PC-60001 |
PF-06821497 S enantiomer
|
PF-06821497 S enantiomer is a novel potent, selective, orally bioavailable EZH2 inhibitor with Ki of <0.1 and 1.15 nM aginast both wt and mutant Y641N EZH2, respectively. |
| PC-45680 |
SGC-707
PRMT3 inhibitor
|
SGC-707 (SGC707) is a potent, selective and cell-active allosteric inhibitor of PRMT3 (IC50=31 nM, Kd=53 nM). |
| PC-45658 |
MS-023
type I PRMTs inhibitor
|
MS-023 is a potent, selective, and cell-active inhibitor of type I PRMTs with IC50s of 30/119/83/4/5 nM for PRMT1/3/4/6/8 respectively. |
| PC-45727 |
MI-538
Menin-MLL inhibitor
|
MI-538 is potent and selective menin-MLL interaction inhibitor (IC50=21 nM). |
| PC-45726 |
MI-463
Menin-MLL inhibitor
|
MI-463 is a highly potent and orally bioavailable small-molecule inhibitor of menin-MLL (IC50=15.3 nM, Kd=9.9 nM). |
