| Cat. No. |
Product Name |
Information |
| PC-61034 |
T-3256336
IAP inhibitor
|
T-3256336 is a potent, selective, orally available IAP antagonist with IC50 of 1.3, 2.2 and 200 nM for cIAP-1, cIAP-2 and XIAP, respectively. |
| PC-70207 |
MV1
IAP inhibitor
|
MV1 is a small-molecule IAP antagonist that binds to select baculovirus IAP repeat (BIR) domains resulting in dramatic induction of auto-ubiquitination activity and rapid proteasomal degradation of c-IAPs. |
| PC-60254 |
AT-IAP
XIAP/cIAP1 inhibitor
|
A potent, orally bioavailable, dual XIAP/cIAP1 inhibitor with EC50 of 5.1/0.32 nM, respectively. |
| PC-45046 |
BV6
IAP inhibitor
|
BV6 is a small molecule, bivalent IAP antagonist that binds to the c-IAP1 and XIAP BIR2-BIR3 domains with Kd of 0.46 and 0.029 nM, respectively. |
| PC-42440 |
YM-155 hydrochloride
Survivin inhibitor
|
YM-155 hydrochloride is a potent, specific survivin inhibitor that inhibits survivin promoter activity with IC50 of 0.54 nM. |
| PC-45289 |
Embelin
XIAP inhibitor
|
Embelin (Embelic acid, Emberine, NSC-91874) is a cell-permeable benzoquinone compound that exhibits antitumor properties, specifically antagonizes XIAP-mediated inhibition of caspase-9 activation by directly targeting the Smac and caspase-9 binding domain BIR3 (IC50=4.1 uM). |
| PC-21421 |
LLP-3
Survivin-Ran inhibitor
|
LLP-3 is a potent inhibitor of Survivin protein interaction, sepcifically inhibits Survivin-Ran complex formation, inhibits glioma stem cells (GSC) survival and growth. |
| PC-21402 |
Birinapant
IAP inhibitor
|
Birinapant (TL32711) is a bivalent, selective small molecule SMAC mimetic, binds with high affinity to multiple members of the IAP family with Kd of 45 nM and <1 nM for XIAP and cIAP1 respectively. |
| PC-20999 |
LBW242
IAP inhibitor
|
LBW242 (LBW-242) is a small molecule Smac-mimetic / inhibitor of apoptosis protein (IAP) antagonist, binds to XIAP (BIR3) with IC50 of 280 nM. |
| PC-20998 |
LCL161
IAP inhibitor
|
LCL161 is a monovalent Smac-mimetic, binds IAPs with high affinity and initiates the destruction of cIAP1 and cIAP2 (encoded by BIRC2 and BIRC3, respectively) and prevention of caspase inhibition by XIAP. |
| PC-20236 |
RMT 5265
SMAC mimetic
|
RMT 5265 (RMT5265) is a potent, small molecule bivalent mimic of Smac, inhibits XIAP and cIAP1/2 through the BIR3 domain. |
| PC-72363 |
SW IV-134
SMAC drug conjugate
|
SW IV-134 is a sigma-2/SMAC drug conjugate, chemically linked the sigma-2 ligand SW43 to the Smac mimetic SW IV-52. |
