| Cat. No. |
Product Name |
Information |
| PC-38683 |
Zabedosertib
IRAK4 inhibitor
|
Zabedosertib (BAY1834845) is a potent, selective IRAK4 inhibitor with IC50 of 3.4 nM, inhibits IRAK4 mediated activation of the TLR/MYD88 pathway. |
| PC-73131 |
HS-243
IRAK1/4 inhibitor
|
HS-243 (HS243) is a highly potent, super-selective IRAK-1/4 inhibitor with IC50 of 24/20 nM, respectively. |
| PC-72011 |
GNE-2256
IRAK4 inhibitor
|
GNE-2256 (GNE2256) is a potent, selective inhibitor of IRAK4 with biochemical Ki of 1.4 nM. |
| PC-36036 |
HG-12-6
|
HG-12-6 is a small-molecule inhibitor that bind preferentially to unphosphorylated IRAK4 with IC50 of 165.1 nM, displays 15-fold selectivity over phosphorylated IRAK4 (IC50=2876 nM). |
| PC-35595 |
R191
|
R191 (R-191) is a potent, small molecule IRAK1/4 kinase inhibitor (IRAK4 IC50=3 nM), exhibits good selectivity against a broad panel of kinases. |
| PC-35135 |
Compound 7004
|
Compound 7004 (IRAK2 mimetic 7004) is a small molecule mimetic of a-helical domain of IRAK2, inhibit IL-33–induced NF-κB transcriptional activity (IC50=9.7 uM) by disrupting Myddosome formation. |
| PC-43498 |
IRAK-1-4 Inhibitor I
|
IRAK-1-4 Inhibitor I is a potent, dual inhibitor of IRAK4 and IRAK1 with IC50 of 0.2 uM and 0.3 uM, respectively. |
| PC-43455 |
IRAK inhibitor 2
|
IRAK inhibitor 2 is a potent IRAK inhibitor.. |
| PC-43454 |
IRAK inhibitor 1
|
IRAK inhibitor 1 is a potent IRAK-4 inhibitor with IC50 of 216 nM, shows little to no activity against JNK-1 and JNK-2 with IC50 of 3.801 uM and >10 uM, respectively.. |
| PC-63079 |
BMS-986126
|
BMS-986126 is a potent, highly selective inhibitor of IRAK4 kinase with IC50 of 5.3 nM, displays >100-fold selective for IRAK4 over a panel of 214 kinases. |
| PC-61623 |
IRAK4 inhibitor 23
|
A potent, selective, orally bioavailable IRAK4 inhibitor with IC50 of 7 nM. |
| PC-61092 |
PF-05387252
|
A potent, selective IRAK4 inhibitor with IC50 of 1.3 nM, 200-fold selectivity over IRAK1 (IC50=290 nM). |
