| Cat. No. |
Product Name |
Information |
| PC-49784 |
A7B7C7
|
A7B7C7 (11-A7B7C7) is a potent Paxillin-α4 integrin binding antagonist with IC50 of 300 nM in vitro, decreases α4β1-mediated T cell migration. |
| PC-49780 |
6-B345TTQ
Paxillin inhibitor
|
6-B345TTQ is a small molecule inhibitor of the α4 integrin-paxillin interaction, impairs the interaction of native paxillin with α4 integrin, decreases α4-mediated cell migration. |
| PC-49560 |
QLT0267
ILK inhibitor
|
QLT-0267 (QLT0267) is a potent, selective inhibitor of integrin-linked kinase (ILK), inhibits the kinase activity of ILK in cell-free assay at 26 nM. |
| PC-49394 |
EMD527040
αvβ6 antagonist
|
EMD527040 (EMD 527040) is a potent, specific, nonpeptidic inhibitor of αvβ6 integrin, inhibits binding of recombinant αvβ6 to fibronectin at 6 nM as compared to >9.5 μM for αvβ3 and αvβ5 integrins. |
| PC-49346 |
TBC4746
VLA-4 inhibitor
|
TBC 4746 (AVA4746) is a small molecule mimetic of VCAM-1 that binds VLA-4 on B-ALL cells with high affinity and efficiently blocks ligand-binding with VCAM-1 with EC50 of 38.52 nM. |
| PC-49345 |
IVL745
VLA-4 inhibitor
|
IVL745 (IVL-745) is a small molecule very late antigen (VLA-4) antagonist with IC50 of 20 nM and 2 nM for adhesion to VCAM-1 and fibronectin, respectively. |
| PC-38812 |
THI0019
VLA-4 agonist
|
THI0019 is a small molecule agonist of the integrin α4β1 (very late antigen-4 or VLA-4) with EC50 of 1.7 uM in cell adhesion assays in which Jurkat cells bound to CS1-conjugated BSA. |
| PC-38467 |
Leukadherin-1
CD11b/CD18 agonist
|
Leukadherin-1 (LA1, GB1275 free base) is a small molecule agonist of leukocyte surface integrin CD11b/CD18, increases CD11b/CD18-dependent cell adhesion to ICAM-1 and reduces deadhesion. |
| PC-73164 |
Cilengitide
Integrin inhibitor
|
Cilengitide (EMD 121974) is a potent, selective, cyclic Arg-Gly-Asp peptide inhibitor of integrins αvβ3 and αvβ5 with IC50 4.1 and 70 nM, respectively. |
| PC-72274 |
GSK3335103
αvβ6 inhibitor
|
GSK3335103 (GSK-3335103) is a potent, oral, small molecule RGD-mimetic αvβ6 integrin inhibitor with pKi of 9.96. |
| PC-35719 |
Valategrast hydrochloride
|
Valategrast hydrochloride is a potent, α4β1 (VLA-4) and α4β7 dual antagonist.. |
| PC-35718 |
Valategrast
|
Valategrast is a potent, α4β1 (VLA-4) and α4β7 dual antagonist.. |
