| Cat. No. |
Product Name |
Information |
| PC-60150 |
ASK1-IN-19
ASK1 inhibitor
|
AKS1-IN-19 is a novel potent, selective and orally active ASK1 (MAP3K5) inhibitor with pIC50 of 8.3. |
| PC-70030 |
Tpl2-IN-2p
Tpl2 inhibitor, Cot/MAP3K8 inhibitor
|
Tpl2-IN-2p is a potent, selective, reversible and ATP-competitive inhibitor of Tpl2 kinase (Cot/MAP3K8) with IC50 of 50 nM. |
| PC-60092 |
GNE-8505
DLK inhibitor
|
GNE-8505 (GNE8505) is a potent, selective and CNS-penetrant inhibitor of dual leucine zipper kinase (DLK, MAP3K12) with Ki of 3 nM. |
| PC-45651 |
NQDI-1
ASK1 inhibitor
|
NQDI-1 is a potent and selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with Ki of 500 nM. |
| PC-45794 |
Tpl2-IN-34
Tpl2 inhibitor, Cot/MAP3K8 inhibitor
|
Tpl2-IN-34 is a potent, selective Tpl2 (cot/MAP3K8) inhibitor with IC50 of 1.6 nM. |
| PC-45565 |
Selonsertib
ASK1 inhibitor
|
Selonsertib (GS-4997) is a highly selective and potent, ATP-competetive inhibitor of ASK1 (Apoptosis Signal-regulating Kinase 1, MAP3K5) with pIC50 of 8.3. |
| PC-20983 |
IACS-52825
DLK inhibitor
|
IACS-52825 is a potent, selective dual leucine zipper kinase (DLK, MAP3K12) inhibitor with binding Kd of 1.3 nM, and IC50 of 107 nM in p-c-Jun cell assays. |
| PC-49571 |
DLK-LZK inhibitor 64
DLK/LZK inhibitor
|
DLK-LZK inhibitor 64 (example 64) is a potent, selective dual leucine zipper kinase (DLK, MAP3K12) and leucine zipper-bearing kinase (LZK) inhibitor with IC50 of 2 nM and 10 nM, respectively. |
| PC-49564 |
DN-1289
DLK/LZK inhibitor
|
DN-1289 (DN1289) is a potent, selective and CNS-penetrant dual inhibitor of leucine zipper kinase (DLK, MAP3K12) and leucine zipper-bearing kinase (LZK, MAP3K13) with IC50 of 17 nM and 40 nM, respectively. |
| PC-38656 |
ASK1 inhibitor 32
ASK1 inhibitor
|
ASK1 inhibitor 32 is a potent, selective and brain penetrant ASK1 inhibitor with cellular IC50 of 25 nM. |
| PC-38374 |
Tilpisertib
TPL2 (MAP3K8) inhibitor
|
Tilpisertib (GS-4875) is a potent, highly selective TPL2 kinase (COT, MAP3K8) inhibitor with IC50 of 1.3 nM, with no significant off-target binding activity. |
