| Cat. No. |
Product Name |
Information |
| PC-49234 |
Y1693
RANKL inhibitor
|
Y1693 is a potent, orally active small-molecule RANKL inhibitor, effectively prevents RANKL-induced osteoclastogenesis (89% inhibition at 1 uM) and bone resorption. |
| PC-73379 |
AS2690168 free base
RANKL inhibitor
|
AS2690168 is a novel orally available, selective RANKL signal transduction inhibitor, reduces TRAP staining of sRANKL-stimulated RAW264 cells with IC50 of 0.28 uM, suppresses RANKL-induced osteoclastogenesis. |
| PC-73378 |
AS2690168
RANKL inhibitor
|
AS2690168 is a novel orally available, selective RANKL signal transduction inhibitor, reduces TRAP staining of sRANKL-stimulated RAW264 cells with IC50 of 0.28 uM, suppresses RANKL-induced osteoclastogenesis. |
| PC-38199 |
Bcl3 inhibitor JS6
Bcl-3 inhibitor
|
Bcl3 inhibitor JS6 is a novel potent, antimetastatic Bcl3 inhibitor, targeting the Bcl3-p50 interaction site. |
| PC-43543 |
BAY 11-7082
Ubc13 inhibitor
|
BAY 11-7082 is a NF-κB inhibitor that selectively and irreversibly inhibits the TNF-α-inducible phosphorylation of IκBα (IC50=10 uM), also inhibits ubiquitin-specific protease USP7 and USP21 with IC50 of 0.19 uM and 0.96 uM, respectively. |
| PC-62804 |
SEMBL
|
SEMBL is a potent NF-κB inhibitor that inhibits DNA binding of NF-κB component p65. |
| PC-62155 |
Withaferin A
|
Withaferin A is a steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity, potently inhibits NF-κB activation by preventing the TNF-induced activation of IKKβ via a thioalkylation-sensitive redox mechanism. |
| PC-60551 |
NDMC101
|
NDMC101 is a small molecule that inhibits NFATc1 and NF-κB activity, inhibits RANKL-induced osteoclastogenesis in vivo. |
| PC-60550 |
ABD328
|
ABD328 (ABD-328) is an orally active, small molecule inhibitor of RANKL and TNF signalling that inhibits inflammation in vivo. |
| PC-42493 |
BAY 11-7085
IκB inhibitor
|
BAY 11-7085 is an inhibitor of the expression of ICAM-1, VCAM-1, and E-selectin in human endothelial cells (IC50=5-10 uM), acts by selectively inhibiting TNFα-induced phosphorylation of IκB-α without affecting the constitutive IκB-α phosphorylation. |
| PC-45134 |
Iguratimod
COX-2 inhibitor, MIF inhibitor
|
Iguratimod (TT-614) is an antirheumatic agent that acts as an inhibitor of COX-2 with IC50 of 20 μM, does not inhibit COX-1, also inhibits macrophage migration inhibitory factor (MIF) with IC50 of 6.81 uM. |
| PC-21743 |
JSH-23
NF-κB inhibitor
|
JSH-23 is a small molecule NF-κB inhibitor, inhibits NF-κB transcriptional activity with IC50 of 7.1 uM in LPS-stimulated macrophages RAW 264.7. |
