| Cat. No. |
Product Name |
Information |
| PC-21657 |
CSB-0914
NF-κB inhibitor
|
CSB-0914 is a small molecule NF-κB inhibitor that stably binds to NF-κB-p50 subunit, exhibits significant efficacy in reducing basophil activation assay induced by FcεRI receptors with IC50 of 98.4 nM. |
| PC-21362 |
AE-848
NF-κB modualator
|
AE-848 is a small molecule modulator of NF-κB and PI3K/AKT/mTOR signaling pathways, shows potent in vitro and in vivo anti-myeloma activity. |
| PC-21026 |
AS2676293
RANKL inhibitor
|
AS2676293 (AS 2676293) is an orally active small-molecule receptor activator of nuclear factor-κB ligand (RANKL) inhibitor, inhibits RANKL-induced osteoclastogenesis using RAW264 cells with IC50 of 0.19 uM. |
| PC-20991 |
EVP4593
nSOC inhibitor
|
EVP4593 (EVP-4593) is an inhibitor of PMA/PHA-induced NF-κB pathway activation with IC50 of 9 nM, inhibits storeoperated calcium (Ca2+) entry (SOC) pathway in huntington's disease (HD) neurons. |
| PC-49360 |
IT848
NF-κB inhibitor
|
IT848 (IT-848) is a potent and specific small molecule NF-κB inhibitor, decreases the affinity of NF-κB all five subunits (Rel A, Rel B, c-Rel, p50 and p52) to their DNA binding sites and disrupts downstream biological events. |
| PC-49334 |
sRANKL inhibitor S3-15
sRANKL inhibitor
|
sRANKL inhibitor S3-15 is a highly potent, orally active inhibitor of soluble RANKL, selectively interrupt soluble RANKL-RANK interaction and without interfering with the membrane RANKL-RANK interaction, shows potent osteoclast inhibition effect with IC50 of 0.19 uM in vitro. |
| PC-47045 |
CRL1101
RelA inhibitor
|
CRL1101 is a small-molecule inhibitor of RelA, binds specifically to RelA (KD=2.3 uM, MST assays) and blockes RelA nuclear translocation in breast cancer cells. |
| PC-47044 |
DHMEQ
NF-κB inhibitor
|
DHMEQ (dehydroxymethylepoxyquinomicin) is an NF-κB inhibitor, inhibits TNF-α-induced activation of NF-κB, and inhibits the TNF-α-induced nuclear accumulation of p65, a component of NF-κB. |
| PC-38805 |
ML236
NF-κB inhibitor
|
ML236 is a potent, B-cell specific NF-κB inhibitor with IC50 of 35 nM, selective for the NF-κB pathway induced by PKC activators (phorbol myristic acetate/ionomycin) and selective for B-cells. |
| PC-38798 |
ML029
NF-κB inhibitor
|
ML029 is a potent and selective probe inhibiting the PKC-initiated NF-kappaB pathway with IC50 of 67 nM. |
| PC-35770 |
SR12460
|
SR12460 (SR-12460) is a novel NF-κB essential modulator (NEMO)-binding domain (NBD) mimetic for inhibiting IKK/NF-κB activation, inhibits TNF-α-mediated NF-κB activation with IC50 of 20.24 uM. |
| PC-35289 |
Edasalonexent
|
Edasalonexent (CAT-1004) is a bifunctional, orally administered small molecule that covalently links 2 compounds known to inhibit NF‐κB, salicylic acid and docosahexaenoic acid (DHA). |
