| Cat. No. |
Product Name |
Information |
| PC-20721 |
PF-4693627
mPGES-1 inhibitor
|
PF-4693627 is a potent, selective and orally bioavailable mPGES-1 inhibitor with IC50 of 3 nM. |
| PC-20720 |
UT-11
mPGES-1 inhibitor
|
UT-11 is a potent microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor, inhibits PGE2 production from human SK-N-AS and murine BV2 cells induced by LPS with IC50 of 0.1 and 2.0 uM, respectively. |
| PC-20005 |
mPGES-1 inhibitor UK-4b
mPGES-1 inhibitor
|
mPGES-1 inhibitor UK-4b is a potent, hgihly selective and orally bioavailable inhibitor of human and mouse mPGES-1 enzymes with IC50 of 33 and 157 nM, respectively, effectively decreases carrageenan-stimulated PGE2 over-production. |
| PC-49705 |
mPGES-1 inhibitor PBCH
mPGES-1 inhibitor
|
PBCH is a selective small-molecule inhibitor of mPGES-1, which is potent and can effectively inhibit both human and rodent orthologs. |
| PC-49642 |
TAS-204
H-PGDS inhibitor
|
TAS-204 (TAS204) is a potent, specific hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, inhibits recombinant human H-PGDS with IC50 of 24.0 nM. |
| PC-49640 |
TFC-007
H-PGDS inhibitor
|
TFC-007 (TFC007) is a potent, specific hematopoietic prostaglandin D synthase (H-PGDS) inhibitor with IC50 of 83 nM. |
| PC-49639 |
HQL-79
H-PGDS inhibitor
|
HQL-79 (HQL79) is an orally selective inhibitor of human hematopoietic prostaglandin D synthase (H-PGDS), inhibits human H-PGDS competitively against the substrate PGH2 and non-competitively against GSH with Ki of 5 and 3 uM, respectively. |
| PC-49638 |
GSK2894631A
H-PGDS inhibitor
|
GSK2894631A (GSK-2894631A) is a potent and specific inhibitor of hematopoietic PGD synthase (HPGDS) with IC50 of 9.9 nM. |
| PC-49465 |
GS-248
mPGES-1 inhibitor
|
Vipoglanstat (GS-248, BI 1029539) is a potent, selective and orally active membrane-associated prostaglandin E synthase-1 (mPGES-1) inhibitor with IC50 of 0.4 nM in human whole-blood assay (hWBA). |
| PC-49237 |
MPO-0144
mPGES-1 inhibitor
|
MPO-0144 (MPO 0144) is a potent, selective mPGES-1 inhibitor (PGE2 IC50=41.77 nM, mPGES-1 IC50=1.16 nM). |
| PC-38688 |
Zaloglanstat
mPGES-1 inhibitor
|
Zaloglanstat (ISC-27864, GRC-27864) is a potent, selective, non-opioid and orally active microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor, exhibits significant analgesic efficacy in preclinical models for osteoarthritis and inflammatory arthritis. |
| PC-38615 |
CAY10526
mPGES-1 inhibitor
|
CAY10526 is an inhibitor of PGE2 production through the selective modulation of mPGES-1 expression, dose-dependently inhibits PGE2 production in LPS-stimulated RAW 264.7 cells with IC50 of 1.8 uM. |
