| Cat. No. |
Product Name |
Information |
| PC-42844 |
PIK-90
DNA-PK/PI3K inhibitor
|
PIK-90 is a potent DNA-PK and PI3K inhibitor that inhibits p110α, p110γ and DNA-PK with IC50s of 11, 18 and 13 nM, respectively. |
| PC-63185 |
AS2541019
PI3Kδ inhibitor
|
AS2541019 is a novel potent, selective, orally active PI3Kδ inhibitor with IC50 of 20.1 nM, >100-fold selectivity over other PI3K isoforms. |
| PC-63013 |
GNE-490
PI3K inhibitor
|
GNE-490 is a potent, selective, orally available class I PI3K inhibitor with IC50 of 3.5/25/5.2/15 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ. |
| PC-62886 |
GNE-293
PI3Kδ inhibitor
|
GNE-293 is a potent and selective PI3Kδ inhibitor with Ki of 0.47 nM, displays 256, 420, 219-fold selectivity over PI3Kα, PI3Kβ, PI3Kγ, respectively. |
| PC-61959 |
DS-7423
PI3K/mTOR inhibitor
|
DS-7423 is a novel potent, small-molecule dual inhibitor of PI3K/mTOR with IC50 of 15.6, 1143, 249, 262 and 34.9 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, and mTOR respectively. |
| PC-61742 |
ST-162
MAPK/PI3K inhibitor
|
ST-162 is a potent, bifunctional MAPK/PI3K antagonist with IC50 of 191 nM and 398 nM for PI3Kα and MEK1, respectively. |
| PC-61741 |
ST-168
MEK/PI3K inhibitor
|
ST-168 is a novel potent, orally available MEK/PI3K bifunctional inhibitor with IC50 of 182, 69.2, 1482, 2293, and 41.7 nM for MEK1, PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively. |
| PC-61127 |
PI3Kδ inhibitor 52
|
ZUN64390 is a potent, selective, and efficacious PI3Kδ inhibitor with IC50 of 1.7 nM, >100-fold selectivitity over PI3Kγ/α/β. |
| PC-60983 |
AMG511
PI3K inhibitor
|
AMG511 (AMG-511) potent, efficacious, and orally available pan class I PI3K inhibitor with Ki of 4/6/2/1 nM for PI3Kα/β/δ/γ, respectively. |
| PC-60567 |
Tenalisib
p110δ/γ inhibitor
|
Tenalisib (RP-6530) is a potent, selective, orally active p110δ/γ PI3K dual inhibitor with IC50 of 24.5 and 33.2 nM, respectively. |
| PC-60527 |
Parsaclisib
PI3Kδ inhibitor
|
Parsaclisib (INCB050465) is a potent and highly selective PI3Kδ inhibitor with IC50 of < 1 nM (SPA). |
| PC-60447 |
LAS191954
PI3Kδ inhibitor
|
LAS191954 is a potent, selective, orally bioavailable PI3Kδ inhibitor with IC50 of 2.6 nM. |
