| Cat. No. |
Product Name |
Information |
| PC-45782 |
GDC-0941 dimethanesulfonate
PI3K inhibitor
|
Pictilisib dimethanesulfonate (GSC-0941) is a potent, selective, orally bioavailable inhibitor of class I PI3Ks with IC50 of 3/33/3/75 nM for p110α/β/γ/δ, respectively. |
| PC-45950 |
NVP-BKM120
PI3K inhibitor
|
NVP-BKM120 (BKM-120, Buparlisib) is a potent, selective, orally bioavailable inhibitor of class I PI3K isoforms with IC50 of 52 nM/166 nM/116 nM/262 nM for p110α/β/δ/γ, respectively. |
| PC-44217 |
NVP-BKM120 hydrochloride
PI3K inhibitor
|
NVP-BKM120 (Buparlisib) hydrochloride potent, selective, orally bioavailable inhibitor of class I PI3K isoforms with IC50 of 52 nM/166 nM/116 nM/262 nM for p110α/β/δ/γ, respectively. |
| PC-45766 |
GDC-0084
PI3K/mTOR inhibitor
|
Paxalisib (GDC-0084, RG-7666) is a potent, selective, brain penetrant dual inhibitor of class I PI3Ks and mTOR with Ki of 2/46/3/10/70 nM for PI3Kα/β/δ/γ/mTOR, respectively. |
| PC-42311 |
AS-605240
PI3Kγ inhibitor
|
AS-605240 (AS605240) is a potent, selective, ATP-competitive, orally active PI3Kγ inhibitor with IC50 of 8 nM. |
| PC-45169 |
Duvelisib
PI3Kδ/γ inhibitor
|
Duvelisib (IPI-145, INK-1197) is a potent, selective PI3Kδ/γ inhibitor with Ki of 23 pM/243 pM, IC50 of 1 nM/50 nM. |
| PC-42319 |
TG100-115
PI3Kγ/δ inhibitor
|
TG100-115 (TG100115) is a potent, selective PI3Kγ/δ with IC50 of 83/235 nM, respectively. |
| PC-42325 |
TGX-221
p110β inhibitor
|
TGX-221 is a potent, selective PI3K p110β inhibitor with IC50 of 8.5 nM. |
| PC-42708 |
GNE-493
PI3K/mTOR inhibitor
|
GNE-493 (GNE493) is a potent, selective dual pan-PI3K/mTOR inhibitor with IC50 of 3.4/12/16/16/32 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR. |
| PC-42544 |
AZD6482
PI3Kβ inhibitor
|
AZD6482 (KIN193) is a potent, selective and ATP competitive PI3Kβ inhibitor with IC50 of 10 nM. |
| PC-42233 |
IPI-549
PI3Kγ inhibitor
|
Eganelisib (IPI-549) is a potent, highly selective, orally active inhibitor of PI3Kγ with IC50 of 16 nM, displays >100-fold selectivity over other lipid and protein kinases (PI3Kα IC50=3.2 uM, PI3Kβ IC50=3.5 uM, PI3Kδ IC50>8.4 uM). |
| PC-44791 |
Voxtalisib
PI3K inhibitor
|
Voxtalisib (XL765, SAR245409) is a potent, highly selective ATP-competitive inhibitor of class I PI3Ks with IC50s of 39/110/43/9 nM for p110α/p110β/p110δ/p120γ. |
