Cat. No. |
Product Name |
Information |
PC-60994 |
AS2521780
|
AS2521780 is a potent, selective, orally bioavailable PKCθ inhibitor that inhibits combinant human PKCθ enzyme with IC50 of 0.48 nM, >30-fold higher than other PKC isoforms. |
PC-42543 |
Sotrastaurin
PKC inhibitor
|
Sotrastaurin (AEB071) is a potent, selective, orally available pan-PKC inhibitor with Ki of 0.22-3.2 nM for PKC isotypes. |
PC-42441 |
Ruboxistaurin hydrochloride
PKCβ inhibitor
|
Ruboxistaurin hydrochloride (LY333531) is a potent, selective, ATP-competitive, orally available PKC beta (PKCβ) inhibitor with IC50 of 4.7 and 5.9 nM for PKCβ I and PKCβ II, respectively. |
PC-42542 |
Enzastaurin
PKCβ inhibitor
|
Enzastaurin (LY317615) is a potent, selective, ATP-competitive PKCβ inhibitor with IC50 of 6 nM. |
PC-42473 |
PKC412
PKC inhibitor
|
Midostaurin (CGP-41231, PKC-412) is a potent, selective PKC inhibitor with IC50 of 50 nM. |
PC-45546 |
Phorbol 12-myristate 13-acetate
PKC activator
|
Phorbol 12-myristate 13-acetate (PMA) is a PKC activator, including group A (α, βI, βII, γ) and group B (δ, ε, η, θ) isoforms. |
PC-21981 |
CIDD-0072424
PKC epsilon inhibitor
|
CIDD-0072424 is a potent, selective inhibitor of protein kinase C epsilon (PKCε, PKC epsilon) with IC50 of 54 nM, high selectivity over other PKC isoforms. |
PC-21446 |
Go 6983
PKC inhibitor
|
Go 6983 is a potent, pan-PKC inhibitor with IC50 of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM against PKCα, PKCβ, PKCγ, PKCδ and PKCζ, respectively. |
PC-20701 |
CRT0066854
aPKC inhibitor
|
CRT0066854 is a potent and selective chemical inhibitor of atypical PKC (protein kinase C) isoforms PKCζ and PKCι with IC50 of 639 nM and 132 nM, respectively. |
PC-38836 |
Z640
aPKC agonist
|
Z640 is a novel non-selective atypical PKC (aPKC) agonist, increases PKCζ and PKCι kinase activity with EC50 of 1.09 and 3.47 µM in vitro kinase activity assays, respectively. |
PC-35396 |
Bryostatin 1
|
Bryostatin 1 (NSC 339555) is a macrocyclic lactone derived from a marine invertebrate, fuctions as an activator of PKC with high binding affinity (Ki=1.35 nM). |
PC-63488 |
PKCiota-IN-51
|
PKCiota-IN-51 is a potent and selective inhibitor of Protein Kinase C iota (PKC-ι) with IC50 of 2.7 nM, >15-fold selectivity over PKC-α and PKC-β. |