| Cat. No. |
Product Name |
Information |
| PC-63027 |
SB-699393
|
SB-699393 is a potent, selective and CNS penetrant B-Raf inhibitor with Kd of 7.2 nM. |
| PC-62206 |
MCP110
Ras/Raf-1 inhibitor
|
MCP110 is a potent Ras/Raf-1 interaction inhibitor. |
| PC-61364 |
Belvarafenib
|
Belvarafenib (HM95573, GDC5573) is a novel potent, selective RAF inhibitor with IC50 of 41 nM, 7 nM and 2 nM for BRAF WT, BRAF V600E and CRAF, respectively. |
| PC-42645 |
GW 5074
c-Raf inhibitor
|
GW 5074 is a potent, selective c-Raf inhibitor with IC50 of 9 nM. |
| PC-42483 |
RAF265
Raf/VEGFR-2 inhibitor
|
RAF265 (CHIR265) is a potent, oral, dual Raf/VEGFR-2 inhibitor with IC50 of 3-60 nM for C-Raf/B-Raf/B-Raf V600E, EC50 of 30 nM for VEGFR2 phosphorylation. |
| PC-45573 |
BGB-283
RAF inhibitor
|
BGB-283 (Lifirafenib, BGB283) is a potent pan RAF inhibitor of BRAF V600E, wt BRAF, CRAFY340/341D and wt ARAF (IC50=5-40 nM). |
| PC-45918 |
PLX-4720
B-Raf V600E inhibitor
|
PLX-4720 (PLX4720 ) is a potent and selective inhibitor of B-Raf V600E with IC50 of 13 nM. |
| PC-42755 |
SB-590885
B-Raf inhibitor
|
SB-590885 is a potent and selective B-Raf inhibitor with Kd of 0.3 nM, >1000 fold selectivity over p38a, GSK3b and Lck. |
| PC-42780 |
AZ 628
B-Raf inhibitor
|
AZ 628(AZ-628, AZ628) is a potent and selective B-Raf inhibitor with IC50s of 2.14 uM and 0.19 uM for wt Braf and Braf V600E respectively.. |
| PC-21593 |
Erianin
Raf-MEK inhibitor
|
Erianin is a small molecule inhibitor of CRAF and MEK1/2 kinases, inhibits constitutive activation of MAPK signaling pathway. |
| PC-21592 |
SHR902275
RAFinhibitor
|
SHR902275 is a potent, selective, and orally active RAF inhibitor targeting RAS mutants with IC50 of 1.6 nM, 10 nM, and 5.7 nM for cRAF, bRAFwt, and bRAFV600E, respectively. |
| PC-21386 |
Uplarafenib
BRAF inhibitor
|
Uplarafenib is a potent, selective small molecule inhibitor of BRAF kinase (IC50=50-100 nM) with antineoplastic activities. |
