| Cat. No. |
Product Name |
Information |
| PC-61974 |
REDX-05358
|
REDX-05358 is a novel potent, highly selective, orally bioavailable pan RAF inhibitor with IC50 of 0.1, 0.68, 0.171, and 0.076 nM for ARAF, BRAF, BRAF (V600E), and CRAF, respectively. |
| PC-61525 |
XL-281
|
XL-281 (BMS 908662) is a potent, selective, orally active inhibitor of wild-type and mutant RAF kinases with anti-tumor activity in multiple xenograft models. |
| PC-70025 |
BRAF inhibitor 13
|
A potent and selective B-Raf inhibitor with IC50 of 0.31 uM and 2 nM for A375 proliferation and A375 p-ERK respectively. |
| PC-42446 |
Sorafenib tosylate
|
A potent, orally available Raf inhibitor with IC50 of 6, 22, and 38 nM for Raf-1, wt Braf, and BRaf V599E, respectively. |
| PC-42445 |
Sorafenib
|
A potent, orally available Raf inhibitor with IC50 of 6, 22, and 38 nM for Raf-1, wt Braf, and BRaf V599E, respectively. |
| PC-42482 |
BRAF inhibitor
|
A potent Raf inhibitor.. |
| PC-45877 |
GDC-0879
|
A potent and selective B-Raf kinase inhibitor with IC50 of 0.13 nM against purified B-Raf V600E and a cellular pERK IC50 of 63 nM in the MALME-3M cell line. |
| PC-45594 |
PLX-7904
|
A potent and selective BRaf inhibitor with IC50 of 5 nM against BRaf V600E in mutant RAS expressing cells. |
| PC-42182 |
RAF-709
|
A novel potent, selective, and orally bioavailable RAF inhibitor with biochemical IC50 of 0.4 nM and 0.5 nM for BRAF and CRAF, respectively. |
| PC-45437 |
RAF-IN-10n
|
A highlt potent and selective BRAF/CRAF inhibitor with IC50 of 24/25 nM, respectively. |
