Cat. No. |
Product Name |
Information |
PC-61152 |
Deltazinone 1
|
Deltazinone 1 (Deltazinone1) is a novel highly selective PDEδ inhibitor that inhibits PDEδ/Ras interaction with Kd of 8±4 nM. |
PC-70154 |
ML-162
|
ML-162 (ML162) is a small-molecule probe that selectively kills cells induced to express mutant RAS, inhibits BJeLR (expressing HRAS G12V) cell lines with IC50 of 25 nM. |
PC-21798 |
SIJ1772
mutated RAS inhibitor
|
SIJ1772 is a potent mutated RAS (mtRAS)-signaling pathway blocker/inhibitor with IC50 of 77 and 96 nM for Ba/F3-NRAS-G12D and Ba/F3-NRAS-G12V, respectively. |
PC-21797 |
SIJ1795
mutated RAS inhibitor
|
SIJ1795 is a potent mutated RAS (mtRAS)-signaling pathway blocker/inhibitor with IC50 of 82 and 75 nM for Ba/F3-NRAS-G12D and Ba/F3-NRAS-G12V, respectively. |
PC-21775 |
ADT-007
Ras inhibitor
|
ADT-007 (ADT007) is a potent, specific pan-RAS inhibitor, shows potential to circumvent resistance to mutant-specific KRAS inhibitors and activates antitumor immunity. |
PC-21686 |
BBO-8956
KRAS G12C inhibitor
|
BBO-8956 is a highly potent, covalent inhibitor of GTP-KRAS G12C, BBO-8956 is effective against both GDP and GTP-bound KRAS G12C. |
PC-21640 |
ASP6918
KRAS G12C inhibitor
|
ASP6918 (ASP 6918) is a highly potent, covalent KRAS G12C inhibitor with IC50 of 28 nM in cell-free assays, and pERK inhibition IC50 of 3.7 nM in NCI-H1373 cells. |
PC-21604 |
Kobe2602
Ras inhibitor
|
Kobe2602 is a small-molecule Ras inhibitor that display antitumor activity by interfering with Ras·GTP-effector interaction, inhibits the binding of H-Ras⋅GTP to c-Raf-1 RBD with Ki of 149 uM. |
PC-21544 |
KRAS G13D inhibitor 41
KRAS G13D inhibitor
|
KRAS G13D inhibitor 41 is a potent, selective KRAS G13D inhibitor with IC50 of 0.41 nM, 29-fold selective over WT KRAS. |
PC-21543 |
K-Ras G12C inhibitor 6
KRAS G12C inhibitor
|
K-Ras(G12C) inhibitor 6 is a potent, irreversible, allosteric inhibitor of the K-Ras(G12C). |
PC-21542 |
CSC01
KRAS G13D inhibitor
|
CSC01 is a small molecule inhibitor of oncogenic KRAS mutant G13D (KRAS-G13D). |
PC-21375 |
AVJ16
Igf2bp1 inhibitor
|
AVJ16 is a specific and potent IGF2BP1 inhibitor, inhibits H1299 wound healing with IC50 of 0.7 uM, interacts with recombinant IGF2BP1 protein with KD of 1.4 uM in MST assays. |