| Cat. No. |
Product Name |
Information |
| PC-49153 |
G12Si-5
K-Ras(G12S) inhibitor
|
G12Si-5 is a specific small molecule that covalently target K-Ras(G12S) mutation, suppresses K-Ras(G12S) signaling, preferentially inhibits the growth of the K-Ras(G12S)-transduced cells with IC50 of 2.4 uM. |
| PC-38706 |
BC-DXI-32982
DX2-KRAS inhibitor
|
BC-DXI-32982 is a specific small molecule DX2-KRAS inhibitor that specifically binds to the KRAS-binding region of AIMP2-DX2, inhibits interaction between DX2 and KRAS4B with IC50 of 0.18 uM. |
| PC-38595 |
APS6-45
RAS/MAPK inhibitor
|
APS6-45 is an orally active tumor-calibrated inhibitor (TCI) that inhibits RAS/MAPK signaling and exhibits antitumor activity. |
| PC-38456 |
Kobe0065
Ras inhibitor
|
Kobe0065 is a small-molecule Ras inhibitor, competitively inhibits the binding of H-Ras⋅GTP to c-Raf-1 RBD with Ki of 46 uM. |
| PC-72832 |
NSC290956
Kras inhibitor
|
NSC290956 is a small molecule inhibitor of KRas with Kd of 21.3 uM. |
| PC-72503 |
K-tetracosapeptide
KARATE inhibitor
|
K-tetracosapeptide (K-TC) is a peptide of 24 amino acids corresponding to the helix a5 in KRAS4B, potent inhibitor of KARATE (KRAS4B-RHOA-mTORC2 Ensemble), specifically targets the KRAS4B-RHOA interaction. |
| PC-72502 |
TAT-K-tetracosapeptide
KARATE inhibitor
|
TAT-K-tetracosapeptide is K-tetracosapeptide fused to a cell-permeable TAT peptide, K-tetracosapeptide (K-TC) is a peptide of 24 amino acids corresponding to the helix a5 in KRAS4B, potent inhibitor of KARATE. |
| PC-72332 |
BI-2852
KRAS inhibitor
|
BI-2852 (BI 2852) is a potent pan-Ras inhibitor, targets GTP-bound KRAS, binds to KRASG12D with a KD of 740 nM (ITC), inhibits GTP-KRAS G12D binding to effectors like SOS1, CRAF and PI3Kα with an IC50 of 490, 770 and 500 nM. |
| PC-72314 |
KRAS G12C Pipetide
|
LVVVGACGVGK |
| PC-72222 |
Chelidonine
STK19 inhibitor
|
Chelidonine (Stylophorin, (+)-Chelidonine) is a potent, selective, ATP-competitive inhibitor of STK19 kinase activity, inhibits STK19-mediated NRAS S89 phosphorylation with IC50 of 125 nM, inhibits NRAS-mediated signaling. |
| PC-72019 |
Rasarfin
Ras-ARF6 inhibitor
|
Rasarfin is a novel dual Ras and ARF6 inhibitor, selectively inhibits small G proteins Ras and ARF6 with IC50 of 7 and 0.7 uM. |
| PC-38332 |
Ras binder compound 3
|
Ras binder compound 3 is a switch-II binding ligand which binds Ras GDP and GTP states, inhibit PI3K activation in vitro.. |
