Cat. No. |
Product Name |
Information |
PC-35089 |
PM-43I
|
PM-43I is a selective inhibitor of STAT5/6 Src Homology 2 (SH2) domain, binds recombinant STAT6 and STAT5B (IC50=1.8 and 3.8 uM) with much lower affinity for STAT3 (IC50=29.9 uM). |
PC-63164 |
TRi-1
TXNRD1 inhibitor
|
TRi-1 (TXNRD1 inhibitor 1) is a potent, specific and irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1) with anticancer potential, 5- to 10-fold higher specificity for TXNRD1 over TXNRD2. |
PC-62556 |
AC-4-130
|
AC-4-130 is a novel, potent STAT5 SH2 domain inhibitor, binds to and efficiently blocks STAT5 activation and subsequent transcriptional activity, shows high selectivity for STAT5 over STAT1 and STAT3. |
PC-62520 |
NSC 370284
|
NSC 370284 is a small molecule that directly binds to and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo. |
PC-62519 |
UC-514321
|
UC-514321 is a more effective analog of NSC-370284 that directly binds to STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo. |
PC-62444 |
Pimozide
|
Pimozide (R6238) is an antipsychotic agent that acts as an antagonist of the D2, D3, and D4 receptors and the 5-HT7 receptor, also is an inhbitor of STAT5. |
PC-62377 |
InS3-54A18
|
InS3-54A18 is an active analog of inS3-54 targeting the DBD of STAT3 with IC50 of 8.8 uM in STAT3-dependent luciferase reporter assay, with increased specificity and pharmacological properties. |
PC-61668 |
FLLL-32
|
FLLL-32 is a cell-permeable analog of curcumin that inhibits JAK2-mediated phosphorylation of STAT3 on Tyr705 in cancer cells (IC50=5 uM). |
PC-61628 |
STAT5b inhibitor 7
|
STAT5b inhibitor 7 (Capstafin prodrug) is the pivaloyloxymethyl ester prodrug of Capstafin, which is a potent, selective STAT5b inhibitor with Ki of 0.34 uM. |
PC-61312 |
IQDMA
STAT3/5 inhibitor
|
IQDMA is a cell-permeable, small molecule inhibitor of the transcription factor STAT5, and dual STAT3/5 degrader (IC50=0.54-1.63 μM). |
PC-61311 |
STAT5-IN-1
|
STAT5-IN-1 is a selective, small molecule inhibitor of the transcription factor STAT5 with IC50 of 47±17 uM in FP assays. |
PC-70249 |
STA-21
|
STA-21 (NSC 628869, Ochromycinone) is a small-molecule inhibitor of STAT3, inhibits Stat3 DNA binding activity, Stat3 dimerization, and Stat3-dependent luciferase activity (20-30 uM). |