| Cat. No. |
Product Name |
Information |
| PC-35856 |
UBCS039
|
UBCS039 (UBCS-039) is the first synthetic activator of the NAD+-dependent protein lysine deacetylase SIRT6 with EC50 of 38 uM. |
| PC-35760 |
MDL-800
SIRT6 activator
|
MDL-800 (MDL800) is a first-in-class, selective, cellular active SIRT6 allosteric activator, increases SIRT6 deacetylation activity with EC50 of 10.3 uM in RHKK-ac-AMC and FDL assays. |
| PC-35584 |
E1231
SIRT1 activator
|
E1231 (E-1231) is a small molecule SIRT1 activator with EC50 of 0.83 uM, interactes with recombinant human SIRT1 protein and deacetylated liver X receptor-alpha (LXRα). |
| PC-63273 |
OSS-128167
SIRT6 inhibitor
|
OSS-128167 is a novel selective, cell permeable SIRT6 inhibitor with IC50 of 89, 1578 and 751 uM for SIRT6, SIRT1 and SIRT2, respectively. |
| PC-63242 |
MC3482
SIRT5 inhibitor
|
MC3482 is a potent, specific SIRT5 inhibitor, increases the ammonia content in cells leading to autophagy and mitophagy, shows selective SIRT5 inhibition vs SIRT1-3.. |
| PC-63189 |
MC 2494
pan-Sirtuin inhibitor
|
MC 2494 is a nove potent, pan-Sirtuin (SirT) inhibitor, increases RIP1 acetylation in the death domain and induces bona fide tumour-restricted acetylated RIP1/caspase-8-mediated apoptosis. |
| PC-63005 |
SRT 2183
SIRT1 activator
|
SRT 2183 is a potent, selective SIRT1 activator with EC1.5 of 0.36 uM, displays good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 uM) and is more potent than Resveratrol. |
| PC-63004 |
SRT1460
SIRT1 activator
|
SRT1460 is a potent, selective SIRT1 activator with EC1.5 of 2.9 uM, displays good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 uM) and is more potent than Resveratrol. |
| PC-62391 |
AEM2
SIRT2 inhibitor
|
SIRT2 inhibitor AEM2 (AEM2) is a selective SIRT2 inhibitor with IC50 of 3.8 uM, shows only weak effects on other sirtuins such as SIRT1, SIRT3, and yeast Sir2. |
| PC-60124 |
SirReal1
Sirt2 inhibitor
|
SirReal1 is novel potent, selective Sirtuin 2 (Sirt2) inhibitor with IC50 of 3.745 uM, displays no inhibitory activity against Sirt1 and Sirt 3 (IC50>100 uM). |
| PC-60123 |
SirReal2
Sirt2 inhibitor
|
SirReal2 (MZ25) is a novel potent, selective Sirtuin 2 (Sirt2) inhibitor with IC50 of 0.435 uM. |
| PC-42642 |
SRT 1720
SIRT1 activator
|
SRT 1720 is a potent, selective SIRT1 activator with EC1.5 of 0.16 uM. |
