| Cat. No. |
Product Name |
Information |
| PC-21414 |
TP-0184
ALK2 inhibitor
|
Itacnosertib (TP-0184) is a novel potent, selective inhibitor of type I bone morphogenetic protein (BMP) receptor ACVR1 (activin A receptor-type 1, ALK2) and FLT3 with IC50 of 8.0 nM (ALK2). |
| PC-21392 |
NUCC-555
Activin inhibitor
|
NUCC-555 is a selective antagonist of Activin antagonist, shows dose-dependent antagonistic activity against activin A-stimulated FSHβ promoter activation in 338FSHβ-luc LβT2 cells with IC50 of 3.67 uM. |
| PC-49711 |
CDD-1115
BMPR2 inhibitor
|
CDD-1115 (CDD1115) is a potent, selective inhibitor of BMP type 2 receptor BMPR2 with IC50 of 1.8 nM and Kiapp of 6.2 nM. |
| PC-49710 |
CDD-1653
BMPR2 inhibitor
|
CDD-1653 (CDD1653) is a potent, selective inhibitor of BMP type 2 receptor BMPR2 with IC50 of 2.8 nM, >360-fold over ALK1, and is inactive versus all other type 1 and type 2 TGFβ family kinases. |
| PC-49109 |
SY-LB-35
BMP receptor agonist
|
SY-LB-35 is a highly effective small molecule full agonist of bone morphogenetic protein (BMP) receptor signaling, significantly increases the cell number and cell viability in the C2C12 myoblast cell line. |
| PC-72935 |
C381
Smad activator
|
C381 (SRI011381) is a first-in-class, CNS bioactive compound capable of restoring lysosomal function with prominent antiinflammatory and neuroprotective activities. |
| PC-72619 |
PF-06952229
TGFbR1 inhibitor
|
PF-06952229 (MDV6058) is a potent, selective and orally active TGFBR1 (ALK5) inhibitor with IC50 of 24 nM. |
| PC-35812 |
AZ12799734
BMP/TGFβ inhibitor
|
AZ12799734 (AZ-12799734) is a pan BMP/TGFβ inhibitor that potently inhibits ligand activated SMAD3/4 transcription with IC50 of 47 nM. |
| PC-35811 |
AZ12601011
TGFBR inhibitor
|
AZ12601011 (AZ-12601011) is a potent, selective inhibitor of ALK4, ALK7 and TGFBR1 (Kd=2.9 nM), inhibits TGFβ-induced reporter activity with IC50 of 18 nM. |
| PC-35519 |
BLU-782
ALK2 inhibitor
|
Fidrisertib (BLU-782) is a potent, selective inhibitor of ALK2 (ACVR1) mutant R206H with IC50 of <10 nM. |
| PC-63322 |
JL5
BMP receptor inhibitor
|
JL5 is a novel potent, selective BMP receptor inhibitor with IC50 of 1, <5 and 2 nM for ALK2/ACVR1, ALK3/BMPR1A and ALK6/BMPR1B, respectively. |
| PC-43408 |
SD-208
TGF-βRI inhibitor
|
SD-208 is a potent, selective TGF-β receptor I kinase (TGF-βRI) inhibitor with IC50 of 48 nM, >100-fold selectivity over TGF-βRII kinase and >20-fold over a panel of related protein kinases. |
