| Cat. No. |
Product Name |
Information |
| PC-21636 |
Ningetinib
MET/AXL inhibitor
|
Ningetinib (CT053PTSA) is a potent, orally bioavailable multikinase inhibitor against c-Met, VEGFR2 as well as Axl, Mer, and FLT3, shows IC50s of 6.7, 1.9 and < 1.0 nM against c-Met, VEGFR-2 and Axl in cell-based assays. |
| PC-20461 |
Tepotinib
MET inhibitor
|
Tepotinib (EMD1214063, MSC2156119) is a potent, specific and ATP-competitive inhibitor of MET (HGFR) with IC50 of 23 nM for MET WT autophosphorylation and 2.2-42.6 nM for M1268T, Y1248H, H1112Y, L1213V, H1112L, V1110I, V1206L, and V1238I MET-mutated variants. |
| PC-20333 |
Merestinib
c-Met inhibitor
|
Merestinib (LY2801653) is a potent, selective, type-II ATP competitive inhibitor of c-Met with Ki of 2 nM, inhibits c-MET wt and mutant Y1230C with IC50 of 42 and 54 nM, respectively. |
| PC-20053 |
BAY-474
c-Met inhibitor
|
BAY-474 (BAY474) is a potent selective inhibitor of c-MET (Tyrosine-protein Kinase Met) with IC50 of <1 nM. |
| PC-49518 |
SYN1143
c-Met/Ron inhibitor
|
SYN1143 (AMG-1) is a potent specific small molecule inhibitor of c-Met kinase and RON with IC50 of 4 and 9 nM, inhibits c-Met signaling and cell proliferation in vitro. |
| PC-49517 |
OSI-296
c-Met/Ron inhibitor
|
OSI-296 is a potent and selective inhibitor of c-MET and RON kinases with cellular IC50 of 42 and 200 nM, respectively. |
| PC-49513 |
XL092
Multikinase inhibitor
|
XL092 (XL-092) is a novel small molecule multi-receptor tyrosine kinase (RTK) inhibitor, targets MET (IC50=3.0 nM), VEGFR2 (IC50=15.0 nM), and the TAM kinases TYRO3, AXL (IC50=5.8 nM), and MER (IC50=0.6 nM). |
| PC-49132 |
Dalmelitinib
c-Met inhibitor
|
Dalmelitinib is a potent, selective c-Met tyrosine kinase inhibitor with IC50 of 0.7 nM, inhibits cell growth of gastric cells SNU5 with IC50 of 2.0 nM, binds to the ATP-binding region of c-MET kinase. |
| PC-36035 |
AMG-458
c-Met inhibitor
|
AMG-458 (AMG458) is a potent, selective, orally bioavailable c-Met inhibitor with Ki of 1.2 nM (human c-Met). |
| PC-35732 |
PLB-1001
MET inhibitor
|
PLB-1001 (Bozitinib, PLB1001, CBI-3103, CBT-101) is a potent, highly selective, ATP-competitive, BBB-permeable MET kinase inhibitor, potently inhibits MET activity by 95.1% at 2 uM. |
| PC-43511 |
Capmatinib
c-MET inhibitor
|
Capmatinib (INCB-28060, INC-280) is a highly potent, selective, ATP competitive inhibitor of c-MET kinase with IC50 of 0.13 nM. |
| PC-43478 |
MK-8033 hydrochloride
|
MK-8033 is a potent, specific, dual c-Met/Ron kinases inhibitor with IC50 of 1/7 nM, also potently inhibits oncogenic c-Met activation loop mutants Y1230C, Y1230H and Y1235D with IC50 of 0.6-1.2 nM. |
