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Clathrin inhibitor

ES9-17 is a non-protonophoric, improved Endosidin9 (ES9) analog that inhibits clathrin heavy chain (CHC) function in both Arabidopsis and human cells, inhibits clathrin-mediated endocytosis (CME).

Endosidin 9

Endocytosis inhibitor

Endosidin 9 (ES9) is a novel mitochondrial uncoupler, and a potent inhibitor of clathrin-mediated endocytosis (CME) in different systems, strongly reduces FM4-64 uptake in Arabidopsis root cells with IC50 of 5 uM.


Clathrin inhibitor

AK306 is a small molecule clathrin heavy chain (CLTC/CHC) binding compound that induces arrest and apoptosis of the HCT116 colon cancer cell line with EC50 of 50 nM.

Pitstop 2

Endocytosis inhibitor

Pitstop 2 is a small molecule inhibitor of clathrin terminal domain and inhibits clathrin-mediated endocytosis.

Pitstop 1

Endocytosis inhibitor

A potent, selective inhibitor of clathrin-independent endocytosis with IC50 of 18 uM (inhibition of clathrin TD-amphiphysin B/C complex formation).


Clathrin inhibitor peptide

Wbox2 is a membrane-permeant peptide that potently inhibits clathrin-mediated endocytosis (CME, IC50=3 uM), binds to SNX9 and AP2 and perturbs clathrin interactions with AP2 and SNX9.

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