| Cat. No. |
Product Name |
Information |
| PC-27763 |
METTL21A-IN-1
METTL21A inhibitor
|
METTL21A-IN-1 (Compound 6d) is a first-in-class, specific inhibitor of protein lysine methyltransferase METTL21A, highly selective against a panel of 44 human MTases. |
| PC-27762 |
HK262
METTL21A inhibitor
|
HK262 is a first-in-class, specific inhibitor of protein lysine methyltransferase METTL21A with IC50 of 1.1 uM. |
| PC-27203 |
TCIP3
p300/CBP-BCL-6 degrader
|
TCIP3 is a cell-permeable lysine acetyltransferase TCIP (KAT-TCIP) and bivalent molecular glue degrader that binds dually to p300/CBP and BCL6, redirects p300/CBP to BCL6, exhibits potent anti-proliferative effect in DLBCL cells. |
| PC-27104 |
MS3-123
PRMT1 inhibitor
|
MS3-123 is a highly potent, selective and covalent inhibitor of PRMT1 with IC50 of 11.4 nM, targeting the unique Cys119 within the SAM-binding pocket of PRMT1. |
| PC-26787 |
TNG456
PRMT5 inhibitor
|
TNG456 is a potent, highly selective, brain-penetrant MTA-cooperative PRMT5 inhibitor with Ki,app of <2 pM, exhibits viability growth inhibition with GI50 of 20 nM for HAP1 MTAP-null cells, 50-fold selective over HAP1 MTAP WT cells. |
| PC-26591 |
NSUN2 inhibitor AK
NSUN2 inhibitor
|
NSUN2 inhibitor AK (AK-968/36977265) is a small molecule inhibitor of RNA methyltransferase NSUN2, decreases m5C occupancy and GATM mRNA levels, shows anti-fibrotic efficacy. |
| PC-26384 |
METTL9i
METTL9 inhibitor
|
METTL9i is a first-in-class, highly potent, selective and cell-active methyltransferase METTL9 inhibitor with IC50 of 67 nM. |
| PC-26021 |
YL-5092
YTHDC1 inhibitor
|
YL-5092 is a highly potent and selective, first-in-class inhibitor of RNA m6A reader YTHDC1 with IC50 of 7.4 nM and SPR Kd of 29.6 nM. |
| PC-25924 |
DC2-C1
YTHDC2 inhibitor
|
DC2-C1 is a potent and cell-active inhibitor of RNA N6-methyladenosine recognition protein YTHDC2 with IC50 of 168 nM in FP assays, high selectivity over other YTH-domain proteins. |
| PC-25914 |
FLAV-27
G9a inhibitor
|
FLAV-27 is a potent, selective, SAM-competitive, brain-penetrant inhibitor of histone methyltransferase G9a with IC50 of 0.6 nM, with excellent selectivity over GLP (3.2% inhibition at 1 uM). |
| PC-25825 |
I3IN-002
IGF2BP3 inhibitor
|
I3IN-002 is a small molecule inhibitor of RNA-binding protein IGF2BP3, inhibits IGF2BP3-RNA interactions and shows leukemic cell growth-inhibitory activity with IC50 of ~2 µM in wild-type SEM-cells. |
| PC-25505 |
KCC-07
MBD2 inhibitor
|
KCC-07 is a potent, selective and BBB-penetrable inhibitor of MBD2 (methyl CpG binding domain protein 2), prevents binding of MBD2 to methylated DNA, reactivates ADGRB1 expression and prevents MDM2-mediated p53 polyubiquitination. |
