| Cat. No. |
Product Name |
Information |
| PC-24113 |
Balomenib
Menin-KMT2A inhibitor
|
Balomenib (Balamenib, ZE63-0302) is an oral small molecule inhibitor of the menin-KMT2A interaction with IC50 of <75 nM, inhibits the growth of MV4-11 (CC50 < 0.1 μM), MOLM-13 (CC50 0.1~0.5 μM) and HEK293 (CC50 < 2 μM). |
| PC-24016 |
EP652
METTL3 inhibitor
|
EP652 is a potent, selective and in vivo active inhibitor of RNA methyltransferase METTL3 with IC50 of 2 nM (METTL3/14) in SPA primary assays. |
| PC-23812 |
DS79932728
G9a/GLP inhibitor
|
DS79932728 is a potent and orally bioavailable histone lysine methyltransferase EHMT2/1 (G9a/GLP) inhibitor with IC50 of 12.6/75.7 nM respectively. |
| PC-23618 |
AS-254s
ASH1L inhibitor
|
AS-254s is a highly potent and selective histone lysine methyltransferase ASH1L (absent, small, or homeotic-like 1) inhibitor with IC50 of 94 nM in FP assays, binds to the catalytic SET domain of ASH1L with ITC Kd of 179 nM. |
| PC-23137 |
UNC10013
SETDB1 modulator
|
UNC10013 is a potent, selective and cell-active covalent ligand/negative allosteric modulator of triple Tudor domain (3TD) of SETDB1 with TR-FRET IC50 of 57 nM, targets the Cys385 of SETDB1. |
| PC-23098 |
Igermetostat
EZH2 inhibitor
|
Igermetostat (XNW5004) is a potent, selective EZH2 inhibitor which potently inhibits both wild type and mutant EZH2. |
| PC-23080 |
DCPT1061
Type I PRMTs inhibitor
|
DCPT1061 is a selective inhibitor of type I PRMT subfamily members, potently inhibits PRMT1, PRMT6, and PRMT8, with less inhibitory effect on PRMT3, PRMT4, and PRMT5 or other epigenetic enzymes. |
| PC-23070 |
ZYZ384
SMYD3 inhibitor
|
ZYZ384 (ZYZ-384) is a small molecule inhibitor of histone lysine methyltransferase SMYD3 with KD value of 78 uM, reduces cell proliferation against human hepatoma HepG2 cells with IC50 of 5.23 uM. |
| PC-23026 |
NSD2 inhibitor 42
NSD2 inhibitor
|
NSD2 inhibitor 42 (W4275) is a potent, selective inhibitor of histone lysine methyltransferase NSD2 with IC50 of 17 nM. |
| PC-22999 |
DOT1L R231Q inhibitor 37
DOT1L R231Q inhibitor
|
DOT1L R231Q inhibitor 37 is a first-in-class DOT1L R231Q inhibitor, inhibits proliferation of H460 cells expressing DOT1LR231Q with IC50 of 6.18 uM. |
| PC-22768 |
Enzomenib
menin-MLL inhibitor
|
Enzomenib (DSP-5336) is a potent, and orally bioavailable menin-MLL interaction inhibitor with IC50 of 1.4 nM, directly binds to the menin protein with Kd of 6 nM. |
| PC-22701 |
W4032
G9a/NSD2 inhibitor
|
G9a/NSD2 dual inhibitor 16 (W4032) is a highly potent G9a/NSD2 dual inhibitor with IC50 of 241/17 nM respectively, shows potent cell growth inhibition against PANC-1 and MDA-MB-231 with IC50 values of 0.44 and 0.72 μM, respectively. |
