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Cat. No. Product Name Information
PC-20516

TAK-279

TYK2 inhibitor

NDI-034858 (Zasocitinib, TAK-279) is a potent, selective and allosteric TYK2 inhibitor, targets TYK2 JH2 domain with binding KD of 3.8 pM.
PC-20143

CEE321

pan JAK inhibitor

CEE321 (CEE-321) is a potent, selective pan-JAK inhibitor with IC50 of 50, 48, 59 and 48 nM for JAK1, JAK2, JAK3 and TYK2, respectively.
PC-49651

CPL409116

JAK/ROCK inhibitor

CPL409116 (CPL 409116) is a potent, competitive, dual JAK and ROCK inhibitor with IC50 of 0.95/5.36//0.87/110.6/106.7 nM for JAK1/JAK2/JAK3/ROCK1/ROCK2, respectively.
PC-49343

VVD-118313

JAK1 inhibitor

VVD-118313 (VVD118313) is a potent, selective and allosteric inhibitor of the non-catalytic pseudokinase domain of JAK1 (C817), blocks JAK1-dependent trans-phosphorylation and cytokine signaling.
PC-49307

AZD0449

JAK1 inhibitor

AZD0449 (AZD-0449) is a potent and highly selective JAK1 inhibitor with IC50 of 2.4 nM, displays >50-fold selectivity over TYK2 and JAK2, and no inhibition against JAK3.
PC-49112

TYK2-JH1 inhibitor 30

TYK2-JH1 inhibitor

TYK2-JH1 inhibitor 30 is a potent and selective TYK2-JH1 inhibitor, shows excellent selectivity, pharmacokinetic properties, and in vivo efficacy in a mouse psoriasis model.
PC-73400

Atinvicitinib

JAK inhibitor

Atinvicitinib is a pyrazole compound and JAK inhibitor with IC50 of 0.4, 6 and 13 nM against JAK1, JAK2, and TYK2, less potent for JAK3 (IC50=1130 nM), has the potential for the research of atopic dermatitis.
PC-73064

LAS194046

pan-JAK inhibitor

LAS194046 (LAS-194046) is a potent, selective pan-JAK inhibitor with IC50 of 5.46/0.4/ 2.07 nM against JAK1/2/3, less potent in TYK2 activity (IC50=21.8 nM).
PC-73037

Deucravacitinib

TYK2 inhibitor

BMS-986165 (Deucravacitinib, BMS986165) is potent, high selective allosteric inhibitor of TYK2 with Ki of 0.02 nM, IC50 of 0.2 nM.
PC-72613

Ropsacitinib

TYK2 inhibitor

Ropsacitinib (PF-06826647) is a potent, selective TYK2 inhibitor with IC50 of 15 nM, inhibits JAK1/2/3 with IC50 of 383/74/>10,000 nM.
PC-72603

AZD4604

JAK1 inhibitor

AZD4604 (AZD-4604) is a, potent, highly selective, ATP-competitive and oral JAK1 inhibitor with IC50 of 0.54 nM, shows >1000-fold selectivity over other JAK family members.
PC-38210

BMS-986202

TYK2 inhibitor

BMS-986202 (BMS 986202) is potent, selective Tyk2 inhibitor that binds to Tyk2 JH2 domain with IC50 of 0.19 nM, Ki of 0.02 nM, >10,000-fold over 273 kinases and pseudokinases.

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