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Cat. No. Product Name Information
PC-49614

AM-5308

AM-5308 is a potent, selective mitotic kinesin KIF18A inhibitor with IC50 of 47 nM in kinesin-8 microtubule (MT)-ATPase motor assays.
PC-49285

BTB-1

BTB-1 (KIF18A inhibitor BTB-1) is a selective and ATP-competitive mitotic kinesin KIF18A inhibitor, BTB-1 potently inhibits the ATPase activity of Kif18A with IC50 of 1.69 uM, does not inhibit other mitotic kinesins.
PC-73363

UMK57

UMK57 (UMK 57) is a small-molecule MACK (alias KIF2C) agonist that specifically potentiates the activity of the kinesin‐13 protein MCAK, suppresses chromosome mis-segregation in chromosomal instability (CIN) cancer cells.
PC-72904

AMG650

AMG650 (Sovilnesib) is an oral, first in class, selective small molecule inhibitor of KIF18A for treatment of advanced solid tumors.
PC-72726

Azo-EMD

Azo-EMD is a cell permeable, photoswitchable compound that inhibits mitotic kinesin Eg5 more potently in its light-induced cis form, used for optical control mitosis.
PC-63578

Kif15-IN-1

Kif15-IN-1 is a potent, selective inhibitor of KIF15 motility, can act synergistically with Eg5 inhibitors to impair cancer cell proliferation..
PC-62405

MAC1

MAC1 (Monastrol Antagonizing Compound 1) is a small molecule that can rescue spindle bipolarity in cells lacking Eg5 activity.

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