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Cat. No. Product Name Information
PC-49302

G2019S-LRRK2 inhibitor 22

G2019S-LRRK2 inhibitor 22 is a novel potent, BBB-penetrant, G2019S-LRRK2 selective kinase inhibitor with IC50 of 4.6 nM, >700-fold selectivity over WT LRRK2.
PC-38909

DNL201

DNL201 (GNE0877) is a first-in-class, CNS-penetrant, selective, ATP-competitive, small-molecule LRRK2 kinase inhibitor with IC50 of 3 nM.
PC-43053

PF-06447475

PF-06447475 is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 of 3 and 11nM for WT LRRK2 and G2019S mutant, respectively.
PC-42142

MLi-2

MLi2 is a potent, selective, orally available and brain-penetrant LRRK2 inhibitor with kinase IC50 of 0.76 nM, cellular IC50 of 1.4 nM (dephosphorylation of LRRK2 pSer935 LRRK2).
PC-45425

GNE-7915 tosylate

GNE-7915 tosylate (GNE7915 tosylate) is a highly potent, selective, and brain-penetrable LRRK2 inhibitor with IC50 of 1.9 nM.
PC-45424

GNE-7915

GNE-7915 is a highly potent, selective, and brain-penetrant LRRK2 inhibitor with IC50 of 1.9 nM.
PC-21271

MK-1468

MK-1468 is a potent, selective, brain-penetrant LRRK2 inhibitor with IC50 of 0.4 nM (G2019S LRRK2), potently inhibits the phosphorylation of LRRK2 serine 935 (pSer935) in hPBMCs with IC50 of 2.8 nM.

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