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Cat. No. Product Name Information
PC-20390

EDG-5506

EDG-5506 (Sevasemten) is a potent, selective, orally active inhibitor of fast skeletal muscle myosin, inhibits fast myofibril ATPase from rabbit psoas muscle with IC50 of 0.2 uM.
PC-38077

Aficamten

Aficamten (CK-274) is a novel next-generation cardiac myosin inhibitor (IC50 =1.4 uM) for treatment of hypertrophic cardiomyopathy.
PC-60047

Mavacamten

Mavacamten (SAR-439152, MYK-461) is a small molecule that reduces contractility by decreasing the ATPase activity of the cardiac myosin heavy chain.
PC-21413

Myosin inhibitor F10

Cardiac-myosin inhibitor F10 is a cardiac-myosin specific and allosteric inhibitor with IC50 of 23 uM on actomyosin ATPase activity.
PC-72702

MT-134

MT-134 (Skeletostatin MT-134) is a selective skeletal myosin II (SkMII) inhibitor with Ki of 0.48 uM, 40- to 170-fold for SkMII over all other myosin II family members.
PC-36046

Myokinasib

Myokinasib is a mixed-type, selective inhibitor of Myosin Light Chain Kinase 1 (MLCK1) with IC50 of 7.9 uM, can bind to the free enzyme and the enzyme-substrate complex.
PC-43535

Blebbistatin S enantiomer

Blebbistatin S enantiomer ((S)-(-)-Blebbistatin) is the S enantiomer of blebbistatin, which is a potent and selective myosin II inhibitor with IC50 of 0.5-5 uM.

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