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Cat. No. Product Name Information
PC-22122

NST-628

RAF-MEK molecular glue

NST-628 is a potent, brain-penetrant, pan-RAF-MEK molecular glue, prevents phosphorylation and activation of MEK by RAF, leading to deep durable inhibition of MEK kinase activity and downstream ERK signaling.
PC-21219

Exarafenib

pan-RAF inhibitor

Exarafenib (KIN-2787) is a highly potent and selective pan-RAF inhibitor with IC50 of 2.4/3.5/1.4 nM for ARAF/BRAF/CRAF, respectively.
PC-73449

Tovorafenib

pan-RAF inhibitor

Tovorafenib (MLN2480, TAK-580) is potent, selective, brain-penetrant RAF dimer antagonist, inhibits MAP kinase pathway signaling in BRAF-mutant melanoma models.
PC-72612

PF-07284890

BRAF V600 mutants inhibitor

PF-07284890 (ARRY-461) is an orally bioavailable, brain penetrant, potent, small molecule BRAF V600 mutants inhibitor, inhibits BRAF and CRAF with IC50 of 5.8 and 4.1 nM, respectively.
PC-72530

TAK-632

pan-RAF inhibitor

TAK-632 (TAK632) is a potent, selective pan-RAF inhibitor with IC50 of 1.4, 2.4 and 8.3 nM for CRAF, BRAF V600E and BRAF WT, respectively.
PC-72469

GNE-9815

pan-RAF inhibitor

GNE-9815 (GNE9815) is a potent, selective, oral Type II pan-RAF inhibitor with Ki of 0.062 and 0.19 nM for CRAF and BRAF, respectively.
PC-72243

BRAF inhibitor Compound Ia

BRAF inhibitor

BRAF inhibitor Compound Ia is a potent, selective, brain penetrant BRAF inhibitor with binding Kd of 0.6, 1.2, and 1.7 nM for BRAF WT, BRAF V600E, and c-RAF, presenting paradox breaker properties.
PC-72242

PLX8394

BRAF inhibitor

PLX8394 (Plixorafenib, PLX-8394) is a next-generation, orally available, small-molecule BRAF inhibitor with IC50 values of 3.8 nM, 14 nM and 23 nM for BRAF (V600E), WT BRAF and CRAF, respectively.
PC-35635

LXH254

RAF inhibitor

LXH254 (Naporafenib, LXH 254) is a highly potent, selective B/C RAF inhibitor with Kd of 1.3/3.6 nM respectively, shows less activity against ARAF.
PC-35347

Balamapimod

Rad

Balamapimod (MKI-833) is an orally active, reversible Ras/Raf/MEK inhibitor developed for antineoplastic potential.
PC-35100

RRD-251

Rb/Raf-1 inhibitor

RRD-251 is a small molecule disruptor of Rb/Raf-1 interaction, potently and selectively disrupts the Rb/Raf-1 (IC50=77 nM) but not Rb/E2F, Rb/prohibitin, Rb/cyclin E, and Rb/HDAC binding.
PC-35099

RRD-251 hydrochloride

Rb/Raf-1 inhibitor

RRD-251 hydrochloride is a small molecule disruptor of Rb/Raf-1 interaction, potently and selectively disrupts the Rb/Raf-1 (IC50=77 nM) but not Rb/E2F, Rb/prohibitin, Rb/cyclin E, and Rb/HDAC binding.

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