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Cat. No. Product Name Information
PC-72802

TAK-981

TAK-981 (TAK981, Subasumstat) is a first-in-class, potent, highly selective SUMO-activating enzyme (SAE) inhibitor with IC50 of 1 nM, >1000-fold selectivity against UAE and NAE.
PC-35900

COH000

COH000 (COH-000) is a highly selective, first-in-class, irreversible, allosteric, covalent inhibitor of SUMO-Activating Enzyme E1, inhibits SUMOylation in vitro with IC50 of 0.2 uM, displays >500-fold selectivity for SUMOylation over ubiquitylation.
PC-60355

IJ-5

A potent, covalent inhibitor of ubiquitin-conjugating enzyme UbcH5 with Kd of 5.189 uM, 3.578 uM, and 2.577 uM for UbcH5a, UbcH5b, and UbcH5c, respectively.
PC-60354

UbcH5c-IN-6d

UbcH5c-IN-6d is a potent, specific, orally bioactive small-molecule inhibitor of ubiquitin-conjugating enzyme UbcH5c with Kd of 283 nM.
PC-60350

ABP-A3

ABP-A3(ABP A3) is an inhibitor of ubiquitin conjugation that targets ubiquitin and Nedd8 E1 enzymes.
PC-60178

TAK-243

TAK-243 (MLN-7243, AOB87172) is a small-molecule, cell-permeable inhibitor of ubiquitin-activating enzyme E1 (UAE1) with IC50 of 1 nM.
PC-20624

DKM 2-93

DKM 2-93 is a covalent, relatively selective inhibitor of ubiquitin-like modifier activating enzyme 5 (UBA5) with IC50 of 430 uM, binds to the catalytic cysteine of UBA5 cysteine 250 (C250).

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