(D)PPA-1 ((D)-PPA 1) | PD-L1 antagonist

Chemical Structure : (D)PPA-1

CAS No.: 1620813-53-7

(D)PPA-1 ((D) PPA-1, (D)PPA 1)

Catalog No.: PC-28253Not For Human Use, Lab Use Only.

(D)PPA-1 ((D)-PPA 1) is a hydrolysis-resistant D-peptide antagonist of PD-1/PD-L1 interaction, binds PD-L1 at an affinity of 0.51 uM in vitro, inhibits PD-1/PD-L1 pathway in vivo.

Packing	Price	Stock
5 mg	$218	In stock
10 mg	$348	In stock
25 mg	$548	In stock
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Biological Activity

(D)PPA-1 ((D)-PPA 1) is a hydrolysis-resistant D-peptide antagonist of PD-1/PD-L1 interaction, binds PD-L1 at an affinity of 0.51 uM in vitro, inhibits PD-1/PD-L1 pathway in vivo.

Physicochemical Properties

M.Wt	1555.65
Formula	C70H98N20O21
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	D-{Asn-Tyr-Ser-Lys-Pro-Thr-Asp-Arg-Gln-Tyr-His-Phe}

References

1. Chang HN, et al. Angew Chem Int Ed Engl. 2015 Sep 28;54(40):11760-4.

2. Feng Y, et al. Biomaterials. 2021 Aug;275:120990.

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(D)PPA-1 ((D) PPA-1, (D)PPA 1)

Biological Activity

Physicochemical Properties

References

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